{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:34:21Z","timestamp":1792510461719,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>To design and validate the first disease\u2010specific quality\u2010of\u2010life instrument for acoustic neuroma, the Penn Acoustic Neuroma Quality\u2010of\u2010Life (PANQOL) scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Prospective instrument validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred forty\u2010three patients with acoustic neuromas completed the 80\u2010question preliminary instrument and the general Short Form\u201036 Health Survey (SF\u201036). A chart review documented patient information. Statistical analysis was performed for item reduction and evaluation of validity criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Analysis of item\u2010total and item\u2010item score correlations eliminated 38 items from the preliminary instrument. Exploratory principal component factor analysis eliminated 16 additional items and identified a natural grouping of remaining items into seven domains, forming the final 26\u2010item PANQOL scale. Test\u2010retest reliability and internal consistency measures for the instrument were high. PANQOL domain scores correlated significantly with related SF\u201036 domain scores and correlated significantly with related visual analogue scale questions given with the preliminary instrument. PANQOL face domain scores showed significant differences across the House\u2010Brackmann grading system scores and correlated inversely with tumor size. No domain in either the PANQOL or SF\u201036 had a strong correlation with pure\u2010tone average or speech discrimination scores. The PANQOL scale discriminated acoustic neuroma cases from controls better than the SF\u201036.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We have developed the first validated disease\u2010specific quality of life instrument for patients with acoustic neuromas. Given the lack of a validated equivalent, this tool has the potential to become a critical outcome measure for studies evaluating treatment of patients with acoustic neuromas. Laryngoscope, 2010<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.20988","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T15:44:00Z","timestamp":1279295040000},"page":"1646-1654","source":"Crossref","is-referenced-by-count":141,"title":["Validation of a disease\u2010specific quality\u2010of\u2010life instrument for acoustic neuroma"],"prefix":"10.1002","volume":"120","author":[{"given":"Brian T.","family":"Shaffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Bigelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ruckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00822.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00182.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.2.205"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"key":"e_1_2_7_6_2","unstructured":"International classification of functioning disability and health (ICF). 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