{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:28:34Z","timestamp":1775813314690,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Background:<\/jats:title><jats:p>The aim of this study is to investigate the predictive value of intraoperative parathormone measurement addressing successful surgical resection in patients with secondary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The study included 42 consecutive patients operated on between May 2006 and July 2008. Patients were grouped according to successful surgery (Group 1, n = 36) and persistent postoperative hyperparathyroidism (Group 2, n = 6). Serum phosphorus (P), total calcium (tCa), ionized calcium (iCa), intact parathormone (iPTH), and alkaline phosphatase (ALP) were drawn preoperatively and intraoperatively upon 15 minutes after completion of resection (iPTH<jats:sub>15<\/jats:sub>). The rate of decrease of pith detected by iPTH<jats:sub>15<\/jats:sub> compared to preoperative values was calculated (iPTH<jats:sub>%<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Preoperative P, tCa, iCa, iPTH, and ALP were comparable. Subtotal parathyroidectomy (sPx) (n = 27) and total parathyroidectomy with autotransplantation (tPx) (n = 15) were performed. Mean iPTH<jats:sub>15<\/jats:sub> value, iPTH<jats:sub>%<\/jats:sub> rates were 145.9 \u00b1 12.3 pg\/mL, % 91.6 \u00b1 0.7, and 522.5 \u00b1 85.4 pg\/mL, % 75.1 \u00b1 2.0 (<jats:italic>P<\/jats:italic> = ,001) in Groups 1 and 2, respectively. Mean serum tCa and iCa at POD#1 in Group 1 were 7.6 \u00b1 0.1 mg\/dL, 0.910 \u00b1 0.4 mmol\/L, and Group 2 were 8.3 \u00b1 0.3 mg\/dL, 1.050 \u00b1 0.4 mmol\/L (<jats:italic>P<\/jats:italic> &lt; .05), respectively. ALP levels were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>iPTH<jats:sub>15<\/jats:sub> value and iPTH<jats:sub>%<\/jats:sub> rate accurately predicts the completeness of resection in secondary hyperparathyroidism. The rate of decrease in serum iPTH detected intraoperatively compared to preoperative baseline levels exceeding 90% in sPx, 95% in tPx, accurately predicts the success of surgery. Postoperative normocalcemia without calcium replacement would raise a suspicion about completeness of surgical resection. Laryngoscope, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21023","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T19:42:39Z","timestamp":1279309359000},"page":"1538-1544","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of intraoperative parathormone measurement for predicting successful surgery in patients undergoing subtotal\/total parathyroidectomy due to secondary 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