{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:27:41Z","timestamp":1789694861611,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T00:00:00Z","timestamp":1278460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To understand Glanzmann's thrombasthenia and provide insight to the management of epistaxis in children with this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>All children diagnosed with Glanzmann's thrombasthenia and treated for epistaxis at Children's Hospitals and Clinics of Minnesota were identified and a retrospective chart review was performed. Outpatient charts, hospitalization records, and operative reports were reviewed from 1999 up to 2009 and appropriate data were extracted. The episodes of epistaxis, therapy used, complications, and success rates for controlling hemorrhage were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Five children with a total of 63 clinical encounters for epistaxis were identified. Forty\u2010seven encounters required hospitalization, close to half of which necessitated medical care in the intensive care unit. Nearly all encounters required infusion of hemostatic therapy with either single or multiple agents. Seventy\u2010one procedures for life\u2010threatening hemorrhage were performed. The most common (n = 24) intervention was administration of bovine collagen matrix, which was successful only half of the time (50%). Anterior and posterior nasal packing with or without hemostatic material completely resolved hemorrhage in 35% of the procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>To date, no form of medical or surgical intervention in children with this condition has consistently demonstrated its ability resolve nasal hemorrhage. The role of the otolaryngologist is to control bleeding during major episodes of nasal hemorrhage that do not respond to medical management. These patients usually have remarkable improvement in the frequency and severity of epistaxis in adolescence and then require much less aggressive therapy. Laryngoscope, 120:2374\u20132377, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21034","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T19:57:04Z","timestamp":1278532624000},"page":"2374-2377","source":"Crossref","is-referenced-by-count":13,"title":["Treatment and outcomes for epistaxis in children with Glanzmann's thrombasthenia"],"prefix":"10.1002","volume":"120","author":[{"given":"R. Raul","family":"Rosas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret Heisel","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-10"},{"key":"e_1_2_6_3_2","first-page":"113","article-title":"Hereditare hammorrhagische thrombasthenie","volume":"88","author":"Glanzmann E.","year":"1918","journal-title":"J Kinderkranken"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029608326165"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537109876951"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01618.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1182\/blood.V86.3.977.977","article-title":"The molecular genetic basis of Glanzmann's thrombasthenia in a gypsy population in France: identification of a new mutation on the alpha IIb gene","volume":"86","author":"Schlegel N","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204513"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.10.3654"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20159"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3160"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04286.x"},{"key":"e_1_2_6_13_2","first-page":"3951","volume":"94","author":"Poon M\u2010C","year":"1999","journal-title":"Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia. Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.7.1383.1383"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1607"},{"key":"e_1_2_6_16_2","first-page":"83","article-title":"Epistaxis in childhood","volume":"17","author":"Petruson B.","year":"1979","journal-title":"Rhinology"},{"key":"e_1_2_6_17_2","first-page":"522","article-title":"Epistaxis in children: causes, diagnosis and treatment","volume":"68","author":"Guarisco JL","year":"1989","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_6_18_2","first-page":"655","article-title":"Clinical use of recombinant human activated factor VII (rFVIIa) in the prevention and treatment of bleeding episodes in patients with Glanzmann's thrombasthenia","volume":"3","author":"Poon M\u2010C.","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00767.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06890.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000160528.50017.3C"},{"issue":"3","key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1288\/00005537-198703000-00014","article-title":"Limited septoplasty as treatment for recurrent epistaxis in a child with Glanzmann's thrombasthenia","volume":"97","author":"Guarisco JL","year":"1987","journal-title":"Laryngoscope"},{"key":"e_1_2_6_23_2","first-page":"1094","article-title":"Glanzmann thrombasthenia successfully operated for nasal deformation with recombinant factor VIIa","volume":"43","author":"Bay A","year":"2006","journal-title":"Indian Pediatr"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:06:07Z","timestamp":1696892767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,24]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1002\/lary.21034"],"URL":"https:\/\/doi.org\/10.1002\/lary.21034","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,24]]}}}