{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:09Z","timestamp":1772118729924,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T00:00:00Z","timestamp":1278460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether the insertion\/deletion polymorphism (\u221294ins\/delATTG) in the promoter of NF\u03baB1 is associated with the risk of bleeding after tonsillectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Setting:<\/jats:title>\n                    <jats:p>Retrospective study with genotyping performed from tonsillar tissue or blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>One hundred forty\u2010eight patients having undergone tonsillectomy due to chronic tonsillitis, with or without posttonsillectomy hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Results:<\/jats:title>\n                    <jats:p>\n                      DNA\u2010extraction from paraffin\u2010embedded tonsillectomy tissue or blood was followed by genotyping for the insertion\/deletion (\u221294ins\/delATTG) promoter NF\u03baB1 polymorphism. Genotypes differed significantly between patients with (n = 56) and without (n = 92) posttonsillectomy hemorrhage, with the frequency of the homozygous deletion genotype carriers (DD) significantly increased in those with posttonsillectomy bleeding with an odds ratio (OR) for bleeding of 3.78 (95% confidence interval [CI] 1.2\u201311.7,\n                      <jats:italic>P<\/jats:italic>\n                      = .023) but not in homozygous (II) insertion and heterozygous (ID) genotype carriers (II\/ID). Genotype distribution in patients was compatible with the Hardy Weinberg equilibrium. In contrast, there were no statistically significant differences between patients with or without posttonsillectomy hemorrhage with regard to demographic characteristics, different surgeons, postoperative medications like analgesics, antibiotics, anticoagulation therapy, or values of variables of pre\u2010 and postoperative coagulation studies. Likewise, these variables revealed no differences between genotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Carriers of the homozygous deletion allele were at an almost fourfold risk to develop posttonsillectomy hemorrhage compared to homozygous and heterozygous insertion allele carriers, independent of other risk factors. Laryngoscope, 2010<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.21050","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T15:58:15Z","timestamp":1278518295000},"page":"1784-1787","source":"Crossref","is-referenced-by-count":3,"title":["Posttonsillectomy hemorrhage: Blame on surgeons or genes?"],"prefix":"10.1002","volume":"120","author":[{"given":"Diana","family":"Arweiler\u2010Harbeck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ender","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Bankfalvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Siffert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt Werner","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Adamzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0699-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005607.pub2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16896-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.08.025"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003591.pub2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0649-4"},{"issue":"7","key":"e_1_2_5_9_2","first-page":"S208","article-title":"Der Insertions\u2010\/Deletionspolymorphismus NF\u2010\u03baB1 (\u221294ins\/delATTG) im Promotor von NF\u2010\u03baB1 beeinflusst die Expression von NF\u03baB1 und Tissue Factor","volume":"49","author":"Adamzik M","year":"2008","journal-title":"An\u00e4st Intens"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704103361506"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.6.2752"},{"issue":"1","key":"e_1_2_5_12_2","first-page":"S9","article-title":"Tissue factor expression by monocytes: regulation and pathophysiological roles","volume":"9","author":"Osterud B","year":"1998","journal-title":"Blood Coagul Fibrinol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2311"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2003.11.028"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199907000-00002"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410807"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:43:19Z","timestamp":1697463799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,23]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/lary.21050"],"URL":"https:\/\/doi.org\/10.1002\/lary.21050","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.6181959.6230055","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,23]]}}}