{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:54:38Z","timestamp":1770483278550,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T00:00:00Z","timestamp":1294099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To evaluate the efficacy of intraoperative mitomycin C (MMC) in endonasal endoscopic dacryocystorhinostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Fifty patients with primary acquired nasolacrimal duct obstruction were enrolled and randomly allocated into the treatment and control group. The patients underwent standard endonasal endoscopic dacryocystorhinostomy with mucosal flaps and mitomycin C or placebo on each group. The ostium size was measured at 3 months, 6 months, and 12 months to evaluate the effect of mitomycin C and placebo, and the patency of the lacrimal drainage system was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>There was no statistical significance in the success rate between the MMC group and the control group at 1\u2010year follow\u2010up (84.6% vs.79.2%, respectively, <jats:italic>P<\/jats:italic> = .59). At the 6\u2010month and 12\u2010month visits, the mean ostium size in the MMC group was 10.8 mm<jats:sup>2<\/jats:sup> (SD = 3.17) and 3.0 mm<jats:sup>2<\/jats:sup> (SD = 1.78), respectively, which were prominently larger than the control group at 7.1 mm<jats:sup>2<\/jats:sup> (SD = 2.62; <jats:italic>P<\/jats:italic> &lt; .001, 95% CI, 0.84\u20135.45) and 1.6 mm<jats:sup>2<\/jats:sup> (SD = 1.18; <jats:italic>P<\/jats:italic> = .004, 95% CI, 0.49\u20132.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>There was no statistically significant difference in the success rates of both groups, but MMC seems to have a conspicuous effect on the healing process at the ostium. Laryngoscope, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21292","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T16:42:22Z","timestamp":1294159342000},"page":"433-436","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy"],"prefix":"10.1002","volume":"121","author":[{"given":"Suppapong","family":"Tirakunwichcha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songklot","family":"Aeumjaturapat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siripong","family":"Sinprajakphon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30910-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00397-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.03.015"},{"key":"e_1_2_6_5_2","first-page":"1","article-title":"Endoscopic dacryocystorhinostomy for acquired nasolacrimal duct obstruction","volume":"13","author":"Agarwal S.","year":"2009","journal-title":"J Laryngol Otol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105470"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","unstructured":"AbrahamLM SelvaD CassonR LeibovitchI.Mitomycin: clinical applications in ophthalmic practice. Drugs2006;66:321\u2013340.","DOI":"10.2165\/00003495-200666030-00005"},{"key":"e_1_2_6_8_2","first-page":"476","article-title":"Dacryocystorhinostomy without intubation with intraoperative mitomycin\u2010C","volume":"16","author":"Rahman A","year":"2006","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01265.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-007-9057-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01676830601174627"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181579795"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181831f56"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199812000-00018"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.1.63"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200003000-00005"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065800782102672"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000103006.49679.23"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","unstructured":"KupperDS DemarcoRC ResendeR Anselmo\u2010LimaWT ValeraFC MoribeI.Endoscopic nasal dacryocystorhinostomy: results and advantages over the external approach. Rev Bras Otorrinolaringol (Engl Ed)2005;71:356\u2013360.","DOI":"10.1016\/S1808-8694(15)31335-5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.1.43"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:28:58Z","timestamp":1697459338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,4]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/lary.21292"],"URL":"https:\/\/doi.org\/10.1002\/lary.21292","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,4]]}}}