{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:38:55Z","timestamp":1792121935956,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary\u2010care pediatric hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective review of consecutive cohort compared with a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed supra\u2010arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age\u2010matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There exists a statistically significant increase in nerve perimeter (\n                      <jats:italic>P<\/jats:italic>\n                      = .001) and nerve surface area (\n                      <jats:italic>P<\/jats:italic>\n                      = .02) in supra\u2010arytenoid specimens in patients with severe laryngomalacia compared with age\u2010matched autopsy supra\u2010arytenoid tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia. Laryngoscope, 2011<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.21360","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T14:25:34Z","timestamp":1294928734000},"page":"627-629","source":"Crossref","is-referenced-by-count":35,"title":["Submucosal nerve hypertrophy in congenital laryngomalacia"],"prefix":"10.1002","volume":"121","author":[{"given":"Patrick D.","family":"Munson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj M.","family":"El\u2010Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Bower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gresham T.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900502"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199003000-00013"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600402"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31804a5750"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00342-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800340058017"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.04.011"},{"key":"e_1_2_6_9_2","first-page":"484","volume-title":"Traiate Clinique et Pratique des Maladies des Enfants","author":"Barthez E","year":"1843"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199207000-00029"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400603"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199711)24:5<364::AID-PPUL9>3.0.CO;2-I"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880060104021"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2083.1561-a"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9811043"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00541-9"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(99)00205-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.02.025"},{"key":"e_1_2_6_19_2","first-page":"721","article-title":"Increased submucosal nerve trunk caliber in aganglionosis","volume":"122","author":"Monforte\u2010Mu\u00f1oz H","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00102.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400504"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225942.33102.9b"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800404"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21360","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:23:45Z","timestamp":1696893825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,13]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/lary.21360"],"URL":"https:\/\/doi.org\/10.1002\/lary.21360","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10142957.10996059","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,13]]}}}