{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:32:10Z","timestamp":1791189130469,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/ Hypothesis:<\/jats:title><jats:p>In general, obstructive sleep apnea (OSA) seems to be a progressive disorder whose pathogenesis is not fully understood. One hypothesis is that long\u2010standing snoring vibrations cause a local neuropathy in the upper airway, which predisposes to obstructive events during sleep. The aim of this study was to investigate sensory function in the upper airway in a cohort of subjects comprising nonsnorers, snorers, and untreated subjects with OSA, and to correlate data to apnea\u2013hypopnea index (AHI) and duration of snoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Cross\u2010sectional cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Subjects were recruited from primary care hypertension clinics. Whole\u2010night respiratory recordings were performed to determine presence and degree of OSA. Three groups were formed based on AHI and snoring history: 1) nonsnorers (n = 25); 2) snorers, AHI &lt; 10 (n = 32); 3) OSA subjects, AHI \u2265 10 (n = 33). Quantitative cold sensory testing of the soft palate and lip was used to assess neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>There were no significant differences concerning lip sensory function between groups. Nonsnorers showed significantly lower thresholds for cold (i.e., better sensitivity) in the soft palate compared to both other groups (<jats:italic>P<\/jats:italic> &lt; .01). Snorers had lower thresholds than OSA subjects (<jats:italic>P<\/jats:italic> &lt; .05). There were significant correlations (<jats:italic>P<\/jats:italic> &lt; .01) between decreased sensory function and AHI (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = .41) and to duration of snoring (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = .47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The degree of sensory neuropathy in the upper airway correlates with degree of obstructive sleep disorder. Our results strengthen the hypothesis that snoring vibrations may cause a neuropathy in the upper airway, which contributes to the progression and development of OSA. Laryngoscope, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21371","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T17:41:30Z","timestamp":1296063690000},"page":"451-456","source":"Crossref","is-referenced-by-count":38,"title":["Soft palate sensory neuropathy in the pathogenesis of obstructive sleep apnea"],"prefix":"10.1002","volume":"121","author":[{"given":"Ola","family":"Sunnergren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Brostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Svanborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.8.1049"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075408"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000196730"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(05)80192-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/oem.52.5.332"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(90)90121-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.2.96-06049"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.06.012"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2747"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.2.2010012"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.866"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.5.585"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.05.002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0317OE"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.2.500"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018536"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00676-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018537"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00728-9"},{"key":"e_1_2_6_21_2","first-page":"1207","article-title":"Heavy snoring as a cause of carotid artery atherosclerosis","volume":"31","author":"Lee SA","year":"2008","journal-title":"Sleep"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21371","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:28:07Z","timestamp":1697459287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,26]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/lary.21371"],"URL":"https:\/\/doi.org\/10.1002\/lary.21371","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,26]]}}}