{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:11:50Z","timestamp":1778818310066,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To measure the change in quality\u2010of\u2010life (QoL) after endoscopic sinus surgery (ESS) in patients with medically recalcitrant chronic rhinosinusitis (CRS) and minimally affected computed tomography (CT) scans of the paranasal sinuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective, multicenter cohort study at three academic, tertiary care centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A total of 778 patients with CRS were enrolled between January 2001 and April 2009 after electing ESS. For the purposes of this analysis, patients with nasal polyposis, history of prior sinus surgery, or follow\u2010up &lt;6 months were excluded. Final study patients were categorized as low\u2010stage CT CRS (Lund\u2010Mackay \u22643; n = 17) and high\u2010stage CT CRS (Lund\u2010Mackay &gt;3; n = 207). Primary outcome measures included two disease\u2010specific QoL instruments: the Rhinosinusitis Disability Index and the Chronic Sinusitis Survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In patients with low\u2010stage CT CRS, a statistically significant improvement was found across all disease\u2010specific QoL scores (all <jats:italic>P<\/jats:italic> \u2264 .012), with the exception of the CSS medication usage subscale (<jats:italic>P<\/jats:italic> = .073). These QoL improvements were comparable to those in patients with high\u2010stage CT CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Some patients will present with CRS that is refractory to medical therapy even though their CT demonstrates relatively minimal disease. Based on the results of this study, ESS is associated with improved QoL in patients with low\u2010stage CT CRS and can provide significant benefit to carefully selected patients with minimally affected CT scans. Laryngoscope, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21382","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T17:41:30Z","timestamp":1296063690000},"page":"417-421","source":"Crossref","is-referenced-by-count":20,"title":["Low\u2010stage computed tomography chronic rhinosinusitis: What is the role of endoscopic sinus surgery?"],"prefix":"10.1002","volume":"121","author":[{"given":"Luke","family":"Rudmik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess","family":"Mace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105922"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900210"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0891-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200402000-00008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980223295-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000192284.22703.04"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119324"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.07.014"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_6_16_2","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110025004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770199-2"},{"key":"e_1_2_6_19_2","first-page":"191","article-title":"Assessing the quality of life for patients with chronic rhinosinusitis using the \u201cRhinosinusitis Disability Index\u201d","volume":"39","author":"Birch DS","year":"2001","journal-title":"Rhinology"},{"key":"e_1_2_6_20_2","first-page":"286","article-title":"Quality of life and impact of surgery on patients with chronic rhinosinusitis","volume":"38","author":"Macdonald KI","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32831b9e2a"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815d74bb"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31814539e8"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3172"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00688.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1258\/002221503321892253"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael180"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21382","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:29:22Z","timestamp":1697459362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,26]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/lary.21382"],"URL":"https:\/\/doi.org\/10.1002\/lary.21382","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,26]]}}}