{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:51:51Z","timestamp":1775785911707,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Second primary tumors (SPTs) are prevalent in head and neck cancer patients. Synchronous SPTs occur within the first 6 months after diagnosis of a first primary tumor. Work\u2010up of first primary head and neck cancers may include panendoscopy if SPTs are suspected. It is unclear whether this strategy has significant impact on treatment results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospectively recorded data on head and neck cancer patients treated at an academic tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The distribution of SPTs was retrieved from a database of 2,016 patients with head and neck cancer. Initial work\u2010up included panendoscopy when an SPT was clinically suspected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Of 2,016 patients, 49 (2.4%) had synchronous SPTs. Of these, there were 26 diagnosed simultaneously with the first primary tumor, of which 18 (69%) were located in areas covered by panendoscopy. The remaining 23 were nonsimultaneous synchronous SPTs; 10 of them were located at sites accessible by panendoscopy, of which 6 were in the bronchial tree. Median survival after simultaneous SPTs was 9 months versus 3 months after nonsimultaneous synchronous SPTs (<jats:italic>P<\/jats:italic>= not significant). The highest frequency of synchronous SPTs was seen with first primary tumors of the hard palate, the dorsum of the tongue, and of the mandibular gingiva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Symptom\u2010directed panendoscopy at initial work\u2010up was successful at finding SPTs of the upper aerodigestive tract, but not SPTs located in the lower airways. Synchronous SPTs missed at initial work\u2010up did not have significantly worse prognosis than simultaneous SPTs. Laryngoscope, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21385","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T17:41:30Z","timestamp":1296063690000},"page":"304-309","source":"Crossref","is-referenced-by-count":33,"title":["Synchronous second primary tumors in 2,016 head and neck cancer patients: Role of symptom\u2010directed panendoscopy"],"prefix":"10.1002","volume":"121","author":[{"given":"Erlend","family":"Rennemo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Z\u00e4tterstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Boysen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199905)21:3<204::AID-HED4>3.0.CO;2-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10444"},{"key":"e_1_2_6_4_2","first-page":"1358","article-title":"Multiple primary malignant tumors: a survey of the literature and a statistical study","volume":"16","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510012273"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn025"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk179"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430310"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21004"},{"key":"e_1_2_6_10_2","first-page":"770","article-title":"Symptom\u2010directed selective endoscopy: long\u2010term efficacy","volume":"127","author":"Benninger MS","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001906714"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0743-y"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hed.21184","article-title":"(18)F\u2010FDG\u2010PET\/CT versus panendoscopy for the detection of synchronous second primary tumors in patients with head and neck squamous cell carcinoma","volume":"32","author":"Haerle SK","year":"2009","journal-title":"Head Neck"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100445"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200201000-00021"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21385","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:17:18Z","timestamp":1712150238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,26]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/lary.21385"],"URL":"https:\/\/doi.org\/10.1002\/lary.21385","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,26]]}}}