{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:19Z","timestamp":1786978159521,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,4]]},"abstract":"Abstract<\/jats:title>\n \n Objectives\/Hypothesis:<\/jats:title>\n To measure health\u2010related and olfaction\u2010related quality of life (QoL) in patients with permanent, severe hyposmia or functional anosmia.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n A case study in a university ENT department of patients with severe olfactory dysfunction defined by Sniffin' Sticks olfactory test kit with a score for odor threshold, discrimination, and identification (TDI) < 20 and a dysfunction lasting longer than 6 months.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Assessment of QoL by using the SF\u201036 Health Survey questionnaire and the Questionnaire for Olfactory Dysfunction (QOD).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 958 patients were tested for smell disturbances from 1999 to 2009. Surveys were mailed to 527 patients who fulfilled the inclusion criteria; 280 (53%) returned completed surveys. All SF\u201036 domains in severely hyposmic and anosmic patients were lower than in the German normal population. Lower SF\u201036 QoL was found for some domains in female patients, older patients, and hyposmic patients (\n P<\/jats:italic>\n < .05 for all groups). Based on the QOD, women showed more parosmia, and anosmic patients had more olfactory\u2010related impairment (\n P<\/jats:italic>\n < .05 for both); in general, higher olfactory impairment and higher parosmia score measured by QOD correlated with lower TDI values (all\n P<\/jats:italic>\n < .05). Multivariate analysis revealed, for SF\u201036 domains, the following independent risk factors: female sex was a risk factor for bodily pain; higher age was a risk factor for physical functioning and role, bodily pain, and general health; hyposmia was a risk factor for bodily pain and mental health; QOD QoL was a risk factor for all SF\u201036 scales; and QOD parosmia was a risk factor for physical role (all\n P<\/jats:italic>\n < .05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n QoL is severely impaired in patients with chronic severe hyposmia or anosmia. The QOD allows a more olfaction\u2010specific assessment of QoL than the SF\u201036 instrument. Laryngoscope, 2011<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.21387","type":"journal-article","created":{"date-parts":[[2011,2,5]],"date-time":"2011-02-05T03:54:09Z","timestamp":1296878049000},"page":"867-872","source":"Crossref","is-referenced-by-count":131,"title":["Health\u2010related and specific olfaction\u2010related quality of life in patients with chronic functional anosmia or severe hyposmia"],"prefix":"10.1002","volume":"121","author":[{"given":"Claudia","family":"Neuland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Marschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Gudziol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"e_1_2_7_2_2","article-title":"Olfactory dysfunctions are substantially more frequent than they are complained [in German]","author":"Marschner H","journal-title":"Laryngol, Rhinol, Otol (Stuttg)"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.6.635"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0796-y"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200410000-00017"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2307"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00026"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0807-9"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410022787"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600801357"},{"key":"e_1_2_7_11_2","first-page":"8","article-title":"Severe nasal polyposis and its impact on quality of life. The effect of a short course of oral steroids followed by long\u2010term intranasal steroid treatment","volume":"44","author":"Alobid I","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00081-X"},{"key":"e_1_2_7_13_2","article-title":"Individual significance of olfaction: development of a questionnaire","author":"Croy I","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050223"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0017502"},{"key":"e_1_2_7_17_2","volume-title":"SF\u201036 Fragebogen zum Gesundheitszustand","author":"Bullinger M","year":"1998"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.497"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.02968.x"},{"issue":"13","key":"e_1_2_7_20_2","first-page":"129","article-title":"Ageing, neurodegeneration, and olfactory and gustatory loss","volume":"5","author":"Welge\u2010Lussen A","year":"2009","journal-title":"B\u2010ENT"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2007.03.007"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21387","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T06:57:28Z","timestamp":1700463448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/lary.21387"],"URL":"https:\/\/doi.org\/10.1002\/lary.21387","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,4]]}}}