{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T12:01:03Z","timestamp":1720094463114},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To investigate the potential usefulness of indirect computed tomography lymphography (CT\u2010LG) with iopamidol in the detection of cervical lymph node metastases in a VX2 rabbit tongue cancer model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Thirty\u2010seven rabbits were randomly divided into control (n = 7) and tongue tumor\u2010bearing (n = 30) groups. In the control group, indirect CT\u2010LG was performed with 0.5\u2010 and 0.25\u2010mL injections of iopamidol in the right and left tongue submucosa, respectively. In the tumor\u2010bearing group, indirect CT\u2010LG with 0.5 mL of iopamidol was performed on day 11 (n = 8), 14 (n = 8), 21 (n = 8), or 28 (n = 6) after carcinoma transplant. The correlation between indirect CT\u2010LG and histopathology was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In normal rabbits, oval or round enhanced cervical lymph nodes in each side of the neck were visualized by indirect CT\u2010LG. In tumor\u2010bearing rabbits, one enhanced lymph node on each side of the neck was visualized with or without filling defects in all rabbits except two on day 28 in which lymph nodes were not enhanced. The sensitivity, specificity, accuracy, and positive and negative predictive values for using filling defects on CT\u2010LG as a diagnostic criterion were 77.4%, 77.8%, 77.6%, 80%, and 75%, respectively. Indirect CT\u2010LG detected 84.6% of 2\u2010 to 6\u2010mm intranodal tumor deposits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Indirect CT\u2010LG may be useful for differentiating metastatic from nonmetastatic lymph nodes. Laryngoscope, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21404","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T20:47:31Z","timestamp":1294174051000},"page":"724-731","source":"Crossref","is-referenced-by-count":9,"title":["Correlative study of indirect computed tomography lymphography using iopamidol and histopathology in a cervical lymph node metastasis model"],"prefix":"10.1002","volume":"121","author":[{"given":"Yilai","family":"Shu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Chodara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Regner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack J.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingliang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816e2eb7"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10170"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.116"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.01.019"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.236035704"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199406001-00011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(96)80331-X"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.17"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903253595"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.07.003"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00473.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1995.tb00232.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0094-0143(21)01689-X","article-title":"Lymphangiography in genitourinary cancer","volume":"12","author":"Voneschenbach AC","year":"1985","journal-title":"Urol Clin North Am"},{"key":"e_1_2_7_15_2","first-page":"29","article-title":"Lymphangiography in ovarian cancer [in Chinese]","volume":"24","author":"Lang JH","year":"1989","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_7_16_2","first-page":"778","article-title":"Establishment of the deep cervical lymph node metastasis model of tongue VX2 carcinoma and observation of its metastatic features [in Chinese]","volume":"43","author":"Ying HY Wu HT","year":"2008","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_7_17_2","article-title":"Assessment of cervical lymph node metastases using indirect CT lymphography with iopamidol in a tongue VX2 carcinoma model","author":"Shu YL","year":"2010","journal-title":"J Laryngol Otol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.6.1791567"},{"key":"e_1_2_7_19_2","first-page":"199","article-title":"Three dimensional changes in lymphatic architecture around VX2 tongue cancer \u2010 dynamic changes after administration of antiangiogenic agent","volume":"36","author":"Seki S","year":"2003","journal-title":"Lymphology"},{"key":"e_1_2_7_20_2","first-page":"755","article-title":"F\u201018\u2010FDG PET\/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT\/MRI","author":"Schoder H","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.8.970"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0097-9"},{"key":"e_1_2_7_23_2","first-page":"1491","article-title":"Which kinds of lymph node metastases can FDG PET detect? 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