{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:37:24Z","timestamp":1788691044714,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T00:00:00Z","timestamp":1304640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>The grainyhead\u2010like 2 gene (<jats:italic>GRHL2<\/jats:italic>) was found to be associated with age\u2010related hearing impairment (ARHI) in Europeans. We tested whether the same association exists in the Han Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Individual cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Among a total of 1,175 Han Chinese volunteers, 310 were classified into the case group (the 26% with poorest hearing), and 308 were placed into the control group (the 26% with best hearing) according to the Z<jats:sub>high<\/jats:sub> scores converted from the original frequency\u2010specific hearing thresholds. The <jats:italic>GRHL2<\/jats:italic> single nucleotide polymorphism locus (rs10955255: A\/G) in intron 1 (coordinate: 102605581) shown in the HapMap was genotyped with correlation to the audiologic phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The genotype distributions of <jats:italic>GRHL2<\/jats:italic> (AA\/AG\/GG) were not significantly different between the control and the case groups (<jats:italic>P<\/jats:italic> = .349). Compared to genotype AA, the odds ratios of the <jats:italic>GRHL2<\/jats:italic> genotypes AG and GG for ARHI were not significantly different after adjustment for other environmental risk factors by logistic regression analyses; 0.78 \u00b1 0.139, 95% confidence interval (CI) = 0.55 \u223c 1.10, <jats:italic>P<\/jats:italic> = .160 for AG; 0.85 \u00b1 0.283, 95% CI = 0.44 \u223c 1.63, <jats:italic>P<\/jats:italic> = .625 for GG. In each audiogram pattern, AA was most common, but the adjusted odds ratios of the genotypes AG and GG for ARHI still were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our results showed no positive association between <jats:italic>GRHL2<\/jats:italic> polymorphisms and ARHI in Han Chinese individuals. Population differences might be a key factor leading to nonreplication of the association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21771","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T16:21:11Z","timestamp":1304698871000},"page":"1303-1307","source":"Crossref","is-referenced-by-count":24,"title":["The grainyhead\u2010like 2 gene (<i>GRHL2<\/i>) single nucleotide polymorphism is not associated with age\u2010related hearing impairment in Han 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