{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:52:56Z","timestamp":1780487576533,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To determine whether patients with Meni\u00e8re's disease can be grouped into distinct subtypes based on a cluster analysis of distinct disease parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective study at a tertiary center associated with a university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The study included 153 patients diagnosed with unilateral definite Meni\u00e8re's disease. The main variables employed were taken from auditory, vestibular, posturographic, and disability assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A four\u2010cluster solution best fitted the data. Each cluster represented a distinct patient profile. Cluster 1 patients (13.1%) were the eldest, with the worst hearing bilaterally and good vestibular function but with a significant postural impact and a low level of disability. Cluster 2 patients (41.2%) were the least affected in all the parameters that were close to normal. Cluster 3 patients (34.6%) were the most affected, experiencing frequent and intense vertigo attacks, and they were visually dependent. Cluster 4 patients (11.1%) had strong asymmetric hearing between both ears and the most uncompensated vestibular deficit; they were moderately disabled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>We have identified four distinct profiles of patients with definite Meni\u00e8re's disease that we consider as \u201cmildly active elderly,\u201d \u201cmildly active young,\u201d \u201cactive compensated,\u201d and \u201cactive uncompensated.\u201d We have demonstrated that only in a restricted population of patients can the American Academy of Otolaryngology\u2013Head and Neck Surgery staging system provide analysis of subtypes of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21844","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T16:16:02Z","timestamp":1311696962000},"page":"1810-1817","source":"Crossref","is-referenced-by-count":14,"title":["Cluster analysis of auditory and vestibular test results in definite meni\u00e8re's disease"],"prefix":"10.1002","volume":"121","author":[{"given":"Lourdes","family":"Montes\u2010Jovellar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Guillen\u2010Grima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Perez\u2010Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium: Guidelines for diagnosing the evaluation of therapy in Meniere's disease","volume":"113","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_3_2","first-page":"357","article-title":"Staging Meniere's disease: description of a 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