{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:04:59Z","timestamp":1791644699382,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>No studies to date have examined the clinical safety and efficacy of carboxymethylcellulose (CMC) for vocal fold injection. The current study investigates the voice outcomes and complications of CMC injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>All patients who underwent CMC injection from three independent sites in a 1\u2010year period were reviewed. Voice outcomes in the form of voice handicap index\u201010 (VHI\u201010) and complications from injection were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Seventy\u2010eight patients with VHI\u201010 results from 1 to 8 weeks after CMC injection were evaluated. Thirty\u2010eight patients were treated for vocal fold immobility, and 15 patients underwent treatment for hypomobility, 15 for vocal fold atrophy, seven for scar\/sulcus, one for previous laryngeal fracture, one for functional dysphonia, and one for persistent granuloma. In 60 patients with available VHI\u201010 data, overall improvement in voice was seen. There was a mean decrease in VHI\u201010 of 7.48 (26.4 to 18.9, <jats:italic>P<\/jats:italic> &lt; .05), correlating to a 19.9% decrease. Forty\u2010five patients (75%) showed a decrease in VHI\u201010, nine (15%) showed an increase, and six (10%) showed no change. Statistically significant differences were seen for patients with immobility (decrease of 8.6, or 31%) and hypomobility (decrease of 10.7, or 37.8%). There were no complications of vocal fold stiffness, inflammatory reaction, or scar in the 78 patients during the total follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>CMC is a viable, safe, and efficacious material for the temporary treatment of glottic insufficiency in vocal fold immobility and hypomobility, with minimal risk of permanent adverse voice outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.21930","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T19:14:26Z","timestamp":1309979666000},"page":"322-326","source":"Crossref","is-referenced-by-count":36,"title":["Safety and efficacy of carboxymethylcellulose in the treatment of glottic insufficiency"],"prefix":"10.1002","volume":"122","author":[{"given":"Pavan S.","family":"Mallur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele P.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory N.","family":"Postma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan R.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark A.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"23","article-title":"Uber eine neue behandlungsmethode der rekurrenslahmung","volume":"18","author":"Bruening W","year":"1911","journal-title":"Verh Dtsch Laryng"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20737"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2008.11.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.01.009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3281084e61"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100307"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201103"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80063-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21122"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400602"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.11.032"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3281084e74"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017701"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.12.035"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21930","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.21930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.21930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:50:42Z","timestamp":1700545842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.21930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,18]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/lary.21930"],"URL":"https:\/\/doi.org\/10.1002\/lary.21930","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,18]]}}}