{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:30:44Z","timestamp":1772087444316,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Is the severity of acute oral mucositis in patients who receive postoperative intensity\u2010modulated radiotherapy (PO\u2010IMRT) for oral tongue squamous cell carcinoma (SCC) reduced by sparing the oral mucosa outside of the planning target volume (PTV)?<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective, randomized trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Forty\u2010eight patients with oral tongue SCC who received PO\u2010IMRT at our institution were randomized to two groups: the oral\u2010sparing (OR\u2010SP) group and oral\u2010unsparing (OR\u2010USP) group. For the OR\u2010SP group (n = 24), the oral mucosa outside of the PTV was spared. Furthermore, the mucosa including the bilateral cheeks, upper lip, and lower lip was defined as the united site and given &lt;32 Gy. For the OR\u2010USP group (n = 24), none of the oral mucosa was protected. The severity of clinical acute mucositis in each patient was assessed weekly during PO\u2010IMRT until completely healed. Oral mucositis was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Dosimetry and therapeutic measures related to acute mucositis between the two groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>During PO\u2010IMRT, no patient experienced grade 4+ acute mucositis in any oral site. Compared to the OR\u2010USP group, there was less grade 2 and 3 mucositis in the united site of the OR\u2010SP group (0% and 25% vs. 45.8% and 54.2%, respectively; <jats:italic>P<\/jats:italic> = .000). Also, the mean dose to the united site was significantly lower with OR\u2010SP compared to OR\u2010USP (41.8 \u00b1 7.4 Gy vs. 58.8 \u00b1 2.2 Gy; <jats:italic>P<\/jats:italic> = .000). The OR\u2010SP group was associated with significant reductions in the use of analgesics (P = .043) and intravenous antibiotics (<jats:italic>P<\/jats:italic> = .039). No recurrences were detected in the vicinity of the spared oral mucosa (the united site) during a median follow\u2010up time of 30 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>OR\u2010SP PO\u2010IMRT for patients with oral tongue SCC resulted in a significant decrease in the severity of acute mucositis and improved quality of life. The sparing of the oral mucosa outside of the PTV is safe and does not compromise oncologic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.22434","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T19:39:25Z","timestamp":1326829165000},"page":"291-298","source":"Crossref","is-referenced-by-count":36,"title":["Protecting the oral mucosa in patients with oral tongue squamous cell carcinoma treated postoperatively with intensity\u2010modulated radiotherapy: A randomized study"],"prefix":"10.1002","volume":"122","author":[{"given":"Zhong\u2010He","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Sheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yong","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21622"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.053"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23898"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2007.10.002"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000178836.68782.b5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0320"},{"key":"e_1_2_7_8_2","article-title":"Impact of salivary gland dosimetry on post\u2010IMRT recovery of saliva output and xerostomia grade for head\u2010and\u2010neck cancer patients treated with or without contralateral submandibular gland sparing: a longitudinal study","author":"Wang ZH","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.02.017"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20601"},{"key":"e_1_2_7_11_2","unstructured":"Cancer therapy evaluation program. 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