{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:47:41Z","timestamp":1792676861676,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To determine whether the endoscopic or sublabial transseptal transsphenoidal approach for pituitary surgery has superior outcomes or decreased complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective meta\u2010analysis of literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A MEDLINE search was conducted identifying all relevant literature in the English language from 1998 through 2010. Studies explicitly identifying pure sublabial or completely endoscopic approaches were included. Meta\u2010analysis comparing the two techniques was performed for multiple outcome measures utilizing a random effects approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 21 endoscopic studies (n = 2,335) and 17 sublabial studies (n = 2,565) met inclusion criteria. Analysis revealed significantly superior rates of gross tumor resection (79% vs. 65%, <jats:italic>P<\/jats:italic> &lt; .0001), as well as lower rates of cerebral spinal fluid leak (5% vs. 7%, <jats:italic>P<\/jats:italic> &lt; .01), septal perforation (0% vs. 5%), and postoperative epistaxis (1% vs. 4%, <jats:italic>P<\/jats:italic> &lt; .0001) for the endoscopic approach compared to the sublabial approach. There was no difference between the two techniques in the incidence of meningitis, diabetes insipidus, or resolution of hormonal abnormality. Hospital stay (<jats:italic>P<\/jats:italic> = .01) was shorter for endoscopic surgery compared to sublabial surgery, and there was no significant difference in terms of length of operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The sublabial transsphenoidal approach has been the gold standard for pituitary surgery for many years. However, meta\u2010analysis of the recent literature demonstrates superior outcomes and decreased postoperative complications with the endoscopic approach, potentially justifying a shift toward endoscopic pituitary surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.22479","type":"journal-article","created":{"date-parts":[[2011,11,26]],"date-time":"2011-11-26T05:06:56Z","timestamp":1322284016000},"page":"511-518","source":"Crossref","is-referenced-by-count":93,"title":["Meta\u2010analysis of endoscopic versus sublabial pituitary surgery"],"prefix":"10.1002","volume":"122","author":[{"given":"Timothy R.","family":"DeKlotz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley H.","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kepher H.","family":"Makambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Aulisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199202000-00016"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198812000-00005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01456170"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347763"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70138-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00512046"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052019"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.1.0044"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1210\/jcem.83.10.5111","article-title":"Transsphenoidal microsurgery for growth hormone\u2010secreting pituitary adenomas: initial outcome and long\u2010term results","volume":"83","author":"Abosch A","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00022"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4065\/74.7.661"},{"key":"e_1_2_6_14_2","first-page":"507","article-title":"Endoscopic pituitary surgery","volume":"46","author":"Heilman CB","year":"2000","journal-title":"Clin Neurosurg"},{"key":"e_1_2_6_15_2","first-page":"301","article-title":"Endoscopic endonasal transsphenoidal surgery for pituitary tumors","volume":"63","author":"Shen CC","year":"2000","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.102118"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240101500604"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0293"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(02)00892-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.5.0967"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147925.04605.cc"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150681.68355.85"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-915635"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000159647.64275.9D"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-830185"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000095534"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2981"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60727-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2008.44.3.151"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000325862.83961.12"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-0135-y"},{"key":"e_1_2_6_32_2","first-page":"425","article-title":"Sublabial transseptal approach to pituitary adenomas with special emphasis on rhinological complications","volume":"18","author":"Er U","year":"2008","journal-title":"Turk Neurosurg"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3246"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2008.25.12.E10"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X298110"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.09.002"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2009.04.012"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.3171\/2007.12.17635"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20949"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.22479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.22479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:34:19Z","timestamp":1700552059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.22479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,17]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/lary.22479"],"URL":"https:\/\/doi.org\/10.1002\/lary.22479","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,17]]}}}