{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:09:40Z","timestamp":1761844180901},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Our objective was to predict the radiosensitivity of human nasopharyngeal carcinoma xenografts in nude mice models through an examination of early changes in apparent diffusion coefficient (ADC) values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Randomized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>BALB\/c\u2010nu nude mice (n = 20) were divided into two groups that were subcutaneously injected with CNE1 or CNE2 cell lines. Xenograft volumes were measured after tumor formation, mice were scanned with a diffusion\u2010weighted imaging sequence, and the mean ADC values were measured (ADC<jats:sub>0<\/jats:sub>). Fifteen to 20 hours after tumors received 15 Gy, mice were scanned again and ADC values (ADC<jats:sub>1<\/jats:sub>) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>ADC<jats:sub>0<\/jats:sub> and ADC<jats:sub>1<\/jats:sub> values of the CNE1 group showed no significant difference (<jats:italic>P<\/jats:italic> = .692). The difference between the ADC<jats:sub>0<\/jats:sub> and ADC<jats:sub>1<\/jats:sub> values of the CNE2 group was statistically significant (<jats:italic>P<\/jats:italic> &lt; .001). ADC<jats:sub>0<\/jats:sub> values of the two groups exhibited no statistically significant difference (<jats:italic>P<\/jats:italic> = .204). ADC<jats:sub>1<\/jats:sub>, ADC<jats:sub>1\u20100<\/jats:sub>, and \u0394ADC of the two groups exhibited statistically significant differences (<jats:italic>P<\/jats:italic> &lt; .001; <jats:italic>P<\/jats:italic> = .001 and .002, respectively). After irradiation, volume changes \u0394V<jats:sub>8<\/jats:sub>, \u0394V<jats:sub>10<\/jats:sub>, and \u0394V<jats:sub>12<\/jats:sub> of two groups were statistically different (all <jats:italic>P<\/jats:italic> &lt; .001). Pearson correlation analysis showed ADC<jats:sub>1\u20100<\/jats:sub> and \u0394ADC were positively correlated with \u0394V<jats:sub>8<\/jats:sub>, \u0394V<jats:sub>10<\/jats:sub>, and \u0394V<jats:sub>12<\/jats:sub>. The cut point was found by means of a receiver operating characteristic curve, and the \u0394V<jats:sub>12<\/jats:sub> of the two redivided groups showed a statistically significant difference (<jats:italic>P<\/jats:italic> = .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This study found that changes in ADC values correlated with volume changes after irradiation. Therefore, ADC values have the potential to predict the radiosensitivity of nasopharyngeal carcinoma xenografts. Laryngoscope, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23208","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T20:35:03Z","timestamp":1330461303000},"page":"839-843","source":"Crossref","is-referenced-by-count":19,"title":["Early changes in apparent diffusion coefficients predict radiosensitivity of human nasopharyngeal carcinoma 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