{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:23:47Z","timestamp":1770517427023,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To assess the utility of imaging in planning intratympanic (IT) gentamicin (Gent) treatment in M\u00e9ni\u00e8re's disease (MD), we compared the dosage and outcomes of ITGent with the severity and extent of endolymphatic hydrops (EH), as evaluated by three\u2010dimensional fluid\u2010attenuated inversion recovery (3D\u2010FLAIR) sequence in a 3\u2010T magnetic resonance imaging (MRI) unit, after IT gadolinium administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A total of 18 patients (10 males and 8 females; age, 28\u201378 years; median age, 53.2 years) with definite MD participated in the investigation. The duration of the disease ranged from 8 months to 9 years (median, 2 years), with a prevalence of vertigo spells ranging from 0.8 to 8 per month (median, 2.2), as calculated in the last 6 months. A 3D\u2010FLAIR MRI was performed 24 hours after IT injection of diluted gadobutrol. ITGent injection was performed within a variable period of time, from 1 week to 3 weeks after 3D\u2010FLAIR MRI. The degree and extension of EH as evaluated by 3D\u2010FLAIR MRI were compared with the number of injections necessary to cure vertigo attacks. Vertigo results, functional level scale modifications, variations in caloric excitability, and pure\u2010tone average modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>No statistically significant correlation was observed between severity of EH and outcomes of ITGent administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The hypothesis of a reduced effect of Gent administered intratympanically in the presence of severe EH, owing to obstacled diffusion along the perilymphatic compartments, has not been confirmed in the present investigation.  Laryngoscope, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23211","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T20:35:33Z","timestamp":1330461333000},"page":"907-911","source":"Crossref","is-referenced-by-count":8,"title":["Variability in the perilymphatic diffusion of gadolinium does not predict the outcome of intratympanic gentamicin in patients with m\u00e9ni\u00e8re's disease"],"prefix":"10.1002","volume":"122","author":[{"given":"Francesco","family":"Fiorino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca B.","family":"Pizzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Beltramello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-0854-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0894"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium Guidelines for the diagnostic and evaluation of therapy in M\u00e9ni\u00e8re's disease","volume":"113","author":"Committee on Hearing and Equilibrium","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_6_2","first-page":"65","article-title":"Clinical nystagmography. 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