{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T05:11:25Z","timestamp":1715145085168},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:00:00Z","timestamp":1332460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective\/Hypothesis:<\/jats:title><jats:p>Several inflammatory and allergic disorders have been reported to correlate with interleukin\u201016 (IL\u201016). IL\u201016 is a highly potent chemotactic and chemoattractant molecule for eosinophils. Nasal polyposis (NP) has an inflammatory basis, and eosinophilia is a common finding in polyp tissue. In this study, we aimed to determine serum IL\u201016 levels in NP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective controlled study in a tertiary academic hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Peripheral blood samples were obtained and used for serologic studies with enzyme\u2010linked immunosorbent assay kits to determine IL\u201016 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The study and the control groups consisted of 17 and 10 patients, respectively. Mean serum IL\u201016 levels were significantly higher in the study group when compared to the control group (447.9 pg\/mL vs. 260.2 pg\/mL) (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Serum IL\u201016 levels are significantly elevated in NP patients. This finding may represent identification of a valuable serum biomarker and potential therapeutic target in NP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23238","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T09:50:20Z","timestamp":1332582620000},"page":"961-964","source":"Crossref","is-referenced-by-count":3,"title":["Serum interleukin\u201016 levels in patients with nasal 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