{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:42:48Z","timestamp":1721191368709},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Contrast\u2010enhanced ultrasound (CE\u2010US) can be used for noninvasive analysis of functional vascularization. Chronically recurrent sialadenitis due to sialolithiasis of the submandibular gland is associated with increased vascularity. The aim of this investigator\u2010initiated clinical trial was the evaluation of CE\u2010US as a quantitative monitoring technique during gland\u2010preserving extracorporeal shock wave sialolithotripsy (ESWL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>In this prospective clinical evidence level 2c study, perfusion in patients (n = 10) with unilateral sialolithiasis of the submandibular gland was quantitatively analyzed using CE\u2010US before and after ESWL, comparing with the respective contralateral gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Before CE\u2010US measurements, a subjective clinical score of complaints (range, 1\u201310) was documented. The contrast agent SonoVue was injected into a cubital vein. The intensity\u2013time curve gradients (ITGs) were calculated from CE\u2010US data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The ITGs derived from CE\u2010US measurements revealed higher perfusion in the affected submandibular gland compared to the contralateral side. In parallel to clinical complaints, parametric CE\u2010US data were significantly reduced after ESWL in chronic sialolithiasis\u2010associated sialadenitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>CE\u2010US\u2013derived ITGs appear to be an independent and quantitative marker for treatment effects of ESWL. Clinical experience and further studies will have to validate this method as a diagnostic tool to decide especially whether to proceed to sialoadenectomy in therapy\u2010refractory cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23281","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T20:35:16Z","timestamp":1334954116000},"page":"1301-1305","source":"Crossref","is-referenced-by-count":4,"title":["Contrast\u2010enhanced ultrasound for monitoring effects of extracorporeal shock wave sialolithotripsy in 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