{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:00:13Z","timestamp":1792731613036,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To evaluate mechanisms of discrepant responses to the nondepolarizing muscle relaxant rocuronium among normal and injured facial nerve\u2010innervated orbicularis oris and tibial nerve\u2010innervated gastrocnemius, and to provide information for the proper use of muscle relaxants to balance evoked electromyography (EEMG) monitoring and immobility in general anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Randomized controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Right\u2010sided facial nerve injury was induced by crush axotomy in 18 Sprague\u2010Dawley rats. At different rocuronium concentrations, muscular tension amplitude (MTA) was determined in vitro for normal and injured facial nerve\u2010innervated orbicularis oris and gastrocnemius; the number of unsaturated acetylcholine receptors (AChRs) at end plates was determined by<jats:sup>125<\/jats:sup>I\u2010\u03b1\u2010bungarotoxin staining followed with gamma spectroscopy. The morphological composition of muscle fibers was determined by histological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Following rocuronium incubation, the percentage of MTA inhibition (MTAI%) of gastrocnemius was significantly higher than the corresponding values of orbicularis oris (<jats:italic>P<\/jats:italic>&lt; .05), and the degree of saturation of AChR in gastrocnemius was significantly greater than that in orbicularis oris (<jats:italic>P<\/jats:italic>&lt; .05). The baseline MTA and AChR density of injured\u2010side orbicularis oris was significantly smaller than those of the normal side, whereas no significant difference was found regarding MTAI% and the degree of AChR saturation between the normal and injured side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The affinity of AChR at end plates and different number of AChR per unit fiber cross\u2010sectional area may be the mechanisms for differential sensitivities to neuromuscular blockers between facial nerve\u2010innervated muscles and somatic nerve\u2010innervated muscles. The lower EEMG responses in the impaired facial nerve\u2010innervated muscles may result from the lower AChR density at end plates compared with the normal facial nerve\u2010innervated muscles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23286","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T20:35:32Z","timestamp":1334954132000},"page":"1831-1837","source":"Crossref","is-referenced-by-count":9,"title":["Differences in sensitivity to rocuronium among orbicularis oris muscles innervated by normal or damaged facial nerves and gastrocnemius muscle innervated by somatic nerve in rats"],"prefix":"10.1002","volume":"122","author":[{"given":"Ru\u2010Yuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Lu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2010Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200005000-00023"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231266.84401.55"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3760\/cma.j.issn.0366-6999.2009.03.014","article-title":"Electromyographic 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