{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:34Z","timestamp":1791999394151,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T00:00:00Z","timestamp":1336348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To detect validity and reliability of the Questionnaire of Olfactory Disorders (QOD) compared to other quality\u2010of\u2010life (QoL) questionnaires, to explore its ability to reflect olfaction\u2010related QoL changes, and to investigate age\u2010 and gender\u2010related effects of olfactory changes on QOD results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>One hundred two patients (56 males, 46 females; mean age, 41.15 \u00b1 16.31 years), suffering from chronic rhinosinusitis, whose olfactory function was measured using Sniffin' Sticks test were studied. All patients completed three validated general health\u2010related QoL questionnaires (Short Form\u201036 Health Survey [SF\u201036], Beck Depression Inventory [BDI], and Zung anxiety scale), and the olfaction\u2010related QOD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Internal consistency and test\u2010retest reliability for the QOD was high. Convergent validity assessment showed statistically significant negative correlations of the QOD and the QOD\u2010negative statements (NS) with overall SF\u201036 score (<jats:italic>P<\/jats:italic> &lt; .05 for all groups) and positive correlations of the same scores with BDI and Zung (<jats:italic>P<\/jats:italic> &lt; .001). The QOD\u2010positive statements (PS) was positively correlated to SF\u201036. Discriminative validity demonstrated statistically significant differences of the QOD and QOD\u2010NS scores between all groups of patients (normosmics, hyposmics, anosmics; all pairwise comparisons, <jats:italic>P<\/jats:italic> &lt; .001). The QOD\u2010PS score was significantly higher in normosmics and hyposmics compared to anosmics. Patients' age was negatively correlated with the QOD\u2010PS, whereas it was positively correlated with BDI (<jats:italic>P<\/jats:italic> &lt; .001) and Zung (<jats:italic>P<\/jats:italic> = .007). Females presented significantly higher scores in the QOD, QOD\u2010NS, BDI, and Zung (all <jats:italic>P<\/jats:italic> &lt; .001) compared to males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The QOD proved to be a valid, reliable, and easy\u2010to\u2010use method of assessment of olfaction\u2010related QoL with high specificity and sensitivity. Laryngoscope, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23349","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T01:25:34Z","timestamp":1334193934000},"page":"1450-1454","source":"Crossref","is-referenced-by-count":125,"title":["Olfaction\u2010associated quality of life in chronic rhinosinusitis: Adaptation and validation of an olfaction\u2010specific questionnaire"],"prefix":"10.1002","volume":"122","author":[{"given":"Efthimios","family":"Simopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Katotomichelakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralampos","family":"Gouveris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Tripsianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltos","family":"Livaditis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Danielides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318184e216"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262779"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjg061"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900606"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0796-y"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600801357"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21387"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1054-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.497"},{"key":"e_1_2_7_12_2","first-page":"273","article-title":"The effect of smoking on the olfactory function","volume":"45","author":"Katotomichelakis M","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000246518.79894.7e"},{"key":"e_1_2_7_15_2","volume-title":"Eysenck\u2010Personlichkeits\u2010Inventar (EPI)","author":"Eggert D","year":"1983"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90142-N"},{"key":"e_1_2_7_17_2","first-page":"337","volume-title":"Quality of Life and Pharmaeconomics in Clinical Trials","author":"Ware JE","year":"1996"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-6014-y"},{"key":"e_1_2_7_19_2","volume-title":"Beck\u2010Depressions\u2010Inventar (BDI)","author":"Hautzinger M","year":"1995"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01482.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3230"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3286"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01828.x"},{"key":"e_1_2_7_25_2","first-page":"377","volume-title":"Clinical Measurement of Taste and Smell","author":"Doty RL","year":"1986"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:13:09Z","timestamp":1700579589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/lary.23349"],"URL":"https:\/\/doi.org\/10.1002\/lary.23349","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,7]]}}}