{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:19:51Z","timestamp":1778822391343,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>\n                      An exploratory US trial in patients with acute rhinosinusitis was conducted to evaluate the efficacy and safety of\n                      <jats:italic>Cyclamen europeaum<\/jats:italic>\n                      extract, a product marketed in Europe that causes reflex nasal discharge and subsequent decongestion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Prospective, randomized, placebo\u2010controlled, double\u2010blind, and parallel group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Outpatients (n = 29) with cardinal symptoms of acute rhinosinusitis and both endoscopic and radiographic (computed tomography [CT] scan) evidence at 25 US centers were randomized to receive intranasal, lyophilized, reconstituted\n                      <jats:italic>Cyclamen europeaum<\/jats:italic>\n                      extract (\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      ) or placebo spray for 7 days. Primary outcomes were reduction in percent sinus opacification on CT scans and reduction in PM predose instantaneous total symptom scores measured on a six\u2010point scale. Secondary outcomes included other measures of symptom score change and endoscopic signs of mucopurulence and inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      treatment significantly reduced sinus opacification compared with placebo treatment (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .045). Although\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      treatment reduced total symptom scores from baseline more than placebo treatment (\u22122.4 vs. \u22121.4), there were no significant treatment group differences (\n                      <jats:italic>P<\/jats:italic>\n                      = .312).\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      treatment was well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      treatment significantly reduced sinus opacification in patients with acute rhinosinusitis. Further exploration of\n                      <jats:italic>Cyclamen<\/jats:italic>\n                      treatment in larger patient populations is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.23366","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T14:59:20Z","timestamp":1338994760000},"page":"1887-1892","source":"Crossref","is-referenced-by-count":17,"title":["An exploratory trial of\n                    <i>Cyclamen europaeum<\/i>\n                    extract for acute rhinosinusitis"],"prefix":"10.1002","volume":"122","author":[{"given":"Jens U.","family":"Ponikau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Hamilos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelique","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cecil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E.","family":"Manthei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"CD000243","article-title":"Antibiotics for acute maxillary sinusitis","volume":"2","author":"Ahovuo\u2010Saloranta A","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_2","first-page":"407","article-title":"Predictors of antibiotic prescribing for non specific upper respiratory infections, acute bronchitis, and acute sinusitis: an UPRNet Study","volume":"49","author":"Dosh SA","year":"2000","journal-title":"J Fam Pract"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.16.1512"},{"key":"e_1_2_7_5_2","first-page":"54","article-title":"Reflex mechanisms of nasoparanasal secretion in the administration of Sinuforte [in Russian]","volume":"3","author":"Gedevanishvili MD","year":"2007","journal-title":"Vestn Otorinolaringol"},{"key":"e_1_2_7_6_2","first-page":"17","article-title":"Quantitative histological and histochemical study of the reaction of the nasal cavity and maxillary sinus glands to contact with Sinuforte [in Russian]","volume":"1","author":"Piskunov SZ","year":"2009","journal-title":"J Russian Rhinol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4193\/Rhino10.096","article-title":"Cyclamen europaeum in the treatment of acute rhinosinusitis: a randomized, double\u2010blind, placebo\u2010controlled trial","volume":"50","author":"Pfaar O","year":"2012","journal-title":"Rhinology"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.037"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.029"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0392"},{"key":"e_1_2_7_11_2","unstructured":"US Food and Drug Administration. 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