{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:44:32Z","timestamp":1785876272799,"version":"3.56.0"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>First bite syndrome (FBS) refers to facial pain characterized by a severe cramping or spasm in the parotid region with the first bite of each meal that diminishes over the next several bites.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib1\">1<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib2\">2<\/jats:ext-link> It is a potential sequela of surgery involving the infratemporal fossa (ITF), parapharyngeal space (PPS), and\/or deep lobe of the parotid gland. The incidence, risk factors, treatment options, and outcomes of FBS are poorly understood. We hypothesized that certain clinical and tumor variables independently predict the development of FBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed the records of 499 patients (mean age, 50 years; range, 12\u201381 years) undergoing surgery of the deep lobe of the parotid gland, PPS, and\/or ITF between 1992 and 2010. Minimum follow\u2010up time was 3 months (median, 39 months). Patient, tumor, and FBS characteristics were analyzed. Incidence was calculated using the Kaplan\u2013Meier method. Univariate analyses and multivariate logistic regression were used to identify independent risk factors for FBS. Patients developing FBS were interviewed to assess the efficacy of various treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>FBS developed in 45 patients (incidence, 9.6%), at a mean time of 97 (range, 6\u2013877) days from surgery. On multivariate analysis, three variables were significant independent risk factors for FBS: sympathetic chain sacrifice (odds ratio [OR], 4.7; <jats:italic>P<\/jats:italic> = .008), PPS dissection (OR, 8.7; <jats:italic>P<\/jats:italic> = .001), and resection of only the deep lobe of the parotid gland (OR, 4.2; <jats:italic>P<\/jats:italic> = .002). FBS developed in 48.6% of patients undergoing sympathetic chain sacrifice, 22.4% of patients undergoing PPS dissection, 38.4% of patients undergoing isolated deep lobe parotid resection, and 0.8% of patients undergoing total parotidectomy. Partial resolution of FBS symptoms occurred in 69% and complete resolution in 12%. Of 45 FBS patients, 15 (33%) underwent at least one type of treatment for symptomatic relief. No treatment consistently provided effective symptomatic relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The strongest independent risk factors for FBS are PPS dissection, deep lobe of parotid resection, and sympathetic chain sacrifice. Patients undergoing surgery with dissection and\/or manipulation in these anatomical sites and structures should be thoroughly counseled about the risk of developing FBS. Laryngoscope, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23372","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T13:07:38Z","timestamp":1336568858000},"page":"1773-1778","source":"Crossref","is-referenced-by-count":98,"title":["First bite syndrome: Incidence, risk factors, treatment, and outcomes"],"prefix":"10.1002","volume":"122","author":[{"given":"Gary","family":"Linkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc G. T.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis H.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.10.1133"},{"key":"e_1_2_6_3_2","unstructured":"NettervilleJL JacksonCG WanamakerJR MillerFR GlasscockME.Vagal paraganglioma: a review of 44 patients treated over 18 years. Presented at the 40th Annual Meeting of American Society for Head and Neck Surgery\/Society of Head and Neck Surgeons at Combined Otolaryngology Spring Meetings; Palm Beach Florida U.S.A.; May 14\u201316 1998."},{"key":"e_1_2_6_4_2","first-page":"275","article-title":"The first\u2010bite syndrome","volume":"34","author":"Haubrich WS","year":"1986","journal-title":"Henry Ford Hosp Med J"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10162"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.06.005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109005180"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21412"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511000294X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21282"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:59:55Z","timestamp":1697461195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,9]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/lary.23372"],"URL":"https:\/\/doi.org\/10.1002\/lary.23372","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,9]]}}}