{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:26Z","timestamp":1786978166782,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>To evaluate the reliability of the sentinel node (SN) biopsy in early oral squamous cell carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 squamous cell carcinomas of the oral cavity between January 2000 and June 2003. Primary results demonstrated a negative predictive value of 100%. The series was then extended until June 2010, with a total number of 166 successful procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort accounted for 118 males and 48 females with a mean age of 56 years. The median follow\u2010up period was 36 months. There were 42 patients (25%) with positive SNs, 14 of them (33%) only harboring micrometastasis. The negative predictive value of the sentinel node biopsy was 95.2%. The SN involvement was strongly correlated with the tumor location (34% of SN+ for the tongue vs. 13% for the floor of mouth,\n                      <jats:italic>P<\/jats:italic>\n                      = .003), tumor stage (18% of SN+ for T1 vs. 40% for T2,\n                      <jats:italic>P<\/jats:italic>\n                      = .002), depth of invasion (median depth for SN+ lesions was 6.5 mm vs. 4 mm for SN\u2212 lesions,\n                      <jats:italic>P<\/jats:italic>\n                      = .028), and lymphovascular involvement (\n                      <jats:italic>P<\/jats:italic>\n                      = .002). The false\u2010negative rate of frozen section examination was 42%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The sentinel node biopsy appears to be an excellent staging method in early oral cancers. This study also provides evidence that routinely undiagnosed micrometastasis may have clinical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.23383","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T18:06:24Z","timestamp":1341252384000},"page":"1782-1788","source":"Crossref","is-referenced-by-count":66,"title":["Sentinel node biopsy in early oral squamous cell carcinomas: A 10\u2010year experience"],"prefix":"10.1002","volume":"122","author":[{"given":"Antoine E.","family":"Melkane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Mamelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Wycisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Temam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Janot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lumbroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80109-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.4.455"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10018"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10213"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800715)46:2<386::AID-CNCR2820460229>3.0.CO;2-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20722"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1724-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.11.024"},{"key":"e_1_2_6_11_2","first-page":"103S","article-title":"Sentinel node biopsy in head and neck cancer","volume":"8","author":"Mozzillo N","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20228"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8777"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1111-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010601)91:11<2077::AID-CNCR1235>3.0.CO;2-E"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.09.001"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0726-8"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-57151-0_16"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20482"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.03.057"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21622"},{"key":"e_1_2_6_22_2","first-page":"A1254","article-title":"Sentinel node procedure in oral carcinoma. 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