{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:33:02Z","timestamp":1790760782274,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Orofacial clefts are the most common craniofacial birth defects in humans, with the majority of orofacial clefts occurring as nonsyndromic cleft lip with or without cleft palate (NSCLP). We previously demonstrated associations between single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>IRF6<\/jats:italic> gene and NSCLP in the Honduran population. Here we investigated other candidate genes and chromosomal regions associated with NSCLP identified from genome\u2010wide association studies (GWAS), including <jats:italic>MAFB<\/jats:italic>, <jats:italic>ABCA4<\/jats:italic>, 8q24, 9q22, 10q25, and 17q22 in two independent Hispanic populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Case\u2010control and family\u2010based association testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Honduran families with two or more members with NSCLP (multiplex) were identified. DNA was collected from affected and unaffected family members (488) and 99 gender\u2010matched controls. NSCLP Colombian families were identified; DNA was collected from 26 proband\u2010parent trios. All participants were genotyped for 17 SNPs in six chromosomal regions. Case\u2010control association and family\u2010based association testing (FBAT) analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Seven SNPs demonstrated association in at least one model in the Honduran population. In the Colombian families, five SNPs demonstrated significance in FBAT when patients with isolated cleft palate (CP) were included; four overlapped with SNPs demonstrating significance in the Honduran population, two with the same allele. One SNP retained significance with CP excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This study supports the previous GWAS findings and is the first to suggest a role for <jats:italic>FOXE1, ABCA4<\/jats:italic>, and <jats:italic>MAFB<\/jats:italic> in orofacial clefting in two separate Hispanic populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23394","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T22:08:11Z","timestamp":1341266891000},"page":"2082-2087","source":"Crossref","is-referenced-by-count":39,"title":["Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations"],"prefix":"10.1002","volume":"122","author":[{"given":"Christen J.","family":"Lennon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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