{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:20:24Z","timestamp":1788495624096,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>To determine whether aggressive surgical management is more effective than local canal resection (LCR) for early\u2010stage temporal bone malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty\u2010three cases of early\u2010stage external auditory canal (EAC) carcinoma who received surgical management between 1993 and 2011 were reviewed. Preoperative computed tomography, enhanced magnetic resonance imaging, pure\u2010tone audiometry, and biopsy were performed. Patients underwent either LCR or lateral temporal bone resection (LTBR). Postoperative pathologic examinations were conducted on all specimens, including assessment of margin status. The duration of the postoperative follow\u2010up period ranged from 6 months to 18 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 26 patients who underwent LCR, 10 were stage T1 and 16 were T2. Positive surgical margins were identified in 14 patients. During the follow\u2010up, 12 patients developed recurrence. Of 17 patients who underwent LTBR with superficial parotidectomy, six were stage T1 and 11 were T2. The lateral EAC margins were negative in all 17 patients. In 2\/6 T1 patients and in 5\/11 T2 patients, tumor cells were identified deep within the EAC cartilage and parotid gland. All of the patients who underwent LTBR survived without evidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LTBR with superficial parotidectomy offers the greatest chance of cure for early\u2010stage EAC carcinoma. Intraoperative frozen sections are necessary to determine the tumor\u2010free lateral EAC margins. Postoperative radiotherapy is not strongly recommended for early\u2010stage EAC carcinoma after LTBR. Laryngoscope, 2013<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.23637","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T15:43:43Z","timestamp":1348501423000},"page":"244-248","source":"Crossref","is-referenced-by-count":68,"title":["Evidence\u2010based surgical management of T1 or T2 temporal bone malignancies"],"prefix":"10.1002","volume":"123","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30318-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840401)53:7<1612::AID-CNCR2820530733>3.0.CO;2-P"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411000303"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400112"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200304000-00008"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.93"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154744.71184.c7"},{"key":"e_1_2_6_9_2","first-page":"582","article-title":"Squamous 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