{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:36:15Z","timestamp":1769283375926,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid treatment in a human phonotrauma model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, individual, randomized, double\u2010blinded, controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 10 healthy females who were randomized to either treatment with oral hydrocortisone or placebo, each given in three doses over 20 hours after the experimental induction of acute phonotrauma. Cytokines associated with inflammation and healing (interleukin [IL]\u20101\u03b2, IL\u20106, IL\u201010) were measured in laryngeal secretions before and after vocal loading and at 4 and 20 hours after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Proinflammatory mediators IL\u20101\u03b2 and IL\u20106 were doubled in the controls versus the steroid treatment group at 21 hours following induction of acute vocal fold inflammation. Anti\u2010inflammatory cytokine IL\u201010 showed a 6.3\u2010fold increase in the steroid treatment group versus the controls, indicating anti\u2010inflammatory modulation by steroid treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides biologic evidence supporting the use of steroids for acute vocal fold inflammation associated with phonotrauma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 124:921\u2013927, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23691","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T17:36:56Z","timestamp":1390930616000},"page":"921-927","source":"Crossref","is-referenced-by-count":27,"title":["Role of steroids in acute phonotrauma: A basic science investigation"],"prefix":"10.1002","volume":"124","author":[{"given":"John W.","family":"Ingle","sequence":"first","affiliation":[{"name":"University of Pittsburgh Voice Center Department of Otolaryngology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah B.","family":"Helou","sequence":"additional","affiliation":[{"name":"Department of Communication Science and Disorders University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Y. K.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences University of Maryland\u2010College Park College Park Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Hebda","sequence":"additional","affiliation":[{"name":"Department of Communication Science and Disorders University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Otolaryngology Wound Healing Research Program Department of Otolaryngology and Pathology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clark A.","family":"Rosen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Voice Center Department of Otolaryngology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine V.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Communication Science and Disorders University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700410"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002789"},{"key":"e_1_2_7_4_1","volume-title":"Biosimulation of Vocal Fold Inflammation And Healing","author":"Li NYK","year":"2009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.08.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201205"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.03.008"},{"key":"e_1_2_7_8_1","first-page":"453","volume-title":"Professional Voice: The Science and Art of Clinical Care","author":"Sataloff RT","year":"1997"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900709"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231455.19183.8c"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0720-x"},{"key":"e_1_2_7_13_1","first-page":"923","article-title":"Steroid injection in chronic inflammatory vocal fold disorders, literature review","volume":"74","author":"Campagnolo AM","year":"2008","journal-title":"Rev Bras Otorrinolaryingol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310001321"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2004\/023)"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000179174.32345.41"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80022-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00101-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9703079"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2009.02.002"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23691","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:38:02Z","timestamp":1696379882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/lary.23691"],"URL":"https:\/\/doi.org\/10.1002\/lary.23691","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}