{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T13:45:50Z","timestamp":1748267150341},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To evaluate the impact of nimodipineon reinnervation of the long\u2010term denervated rat thyroarytenoid (TA) muscle following nerve\u2010muscle pedicle flap (NMP) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design:<\/jats:title><jats:p>Quantitative histologic and physiologic assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Using 120 Wistar rats, we performed NMP implantation at different times after transection of the left recurrent laryngeal nerve (RLN). Sixty animals received nimodipine treatment (NIMO [+] group), and the remaining 60 animals received no nimodipine treatment (NIMO [\u2212] group). As a control, an additional 28 animals were subjected only to transection of the left RLN (DNV group). Subgroups were assigned based on the period after RLN transection (0 [immediate], 8, 16, and 32 weeks). In the DNV group, we assessed histologically the muscle area, axons, neuromuscular junctions (NMJs), and myosin heavy chains (MyHC) type IIA and IIB in the TA muscle. In the NIMO (\u2212) and NIMO (+) groups, histologic assessments and evoked electromyography were performed on the TA muscle at 10 weeks post\u2010NMP implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In 8\u2010week interval subgroups, the muscle fiber area and the number of NMJs in the NIMO (+) group were significantly greater than in the NIMO (\u2212) group (<jats:italic>P<\/jats:italic> &lt; 0.05, each). In the 0\u2010week and 32\u2010week interval subgroups, the muscle fiber subtype changed significantly, from IIA to IIB (<jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> &lt; 0.05, respectively); and, at all time\u2010points the muscle fiber area, number of NMJs, and action potentials in the TA muscle tended to be greater in the NIMO (+) group than in the NIMO (\u2212) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Nimodipine expedited the effects of NMP implantation on reinnervation of the long\u2010term denervated TA muscle. Laryngoscope, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23698","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T18:58:32Z","timestamp":1347303512000},"page":"952-959","source":"Crossref","is-referenced-by-count":11,"title":["The impact of nimodipine administration combined with nerve\u2010muscle pedicle implantation on long\u2010term denervated rat thyroarytenoid muscle"],"prefix":"10.1002","volume":"123","author":[{"given":"Kohei","family":"Nishimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kumai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Sanuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosei","family":"Minoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Yumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.4.384"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199612000-00015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199812000-00002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700109"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000217588.46645.FA"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016480902814280"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1844"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1273"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01041.1996"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90231-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600811"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800112"},{"key":"e_1_2_6_14_2","article-title":"Nimodipine accelerates re\u2010innervation of denervated rat thyroarytenoid muscle following nerve\u2010muscle pedicle implantation","author":"Nishimoto K","year":"2011","journal-title":"Laryngoscope"},{"key":"e_1_2_6_15_2","article-title":"Nimodipine promotes regeneration of peripheral facial nerve function after traumatic injury following maxillofacial surgery: an off label pilot\u2010study","author":"Scheller K","year":"2011","journal-title":"J Craniomaxillofac Surg"},{"issue":"6","key":"e_1_2_6_16_2","first-page":"73","article-title":"Pharmacokinetics and metabolism of calcium\u2010blocking agents nifedipine, nitrendipine, and nimodipine","volume":"1","author":"Ramsch KD","year":"1986","journal-title":"Am J Nephrol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200111000-00001"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03886.1995"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199707)248:3<346::AID-AR7>3.0.CO;2-N"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.6.2507"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.9.1070"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200503"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23698","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:20:48Z","timestamp":1700673648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,10]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/lary.23698"],"URL":"https:\/\/doi.org\/10.1002\/lary.23698","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,10]]}}}