{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:59:41Z","timestamp":1791583181939,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Ostiomeatal complex (OMC) occlusion may play a role in the pathogenesis of some chronic rhinosinusitis (CRS) subgroups, but its role in diffuse mucosal inflammation is strongly debated. The association between radiological OMC occlusion and its draining sinuses in patients with eosinophilic rhinosinusitis (ECRS) compared to non\u2010ECRS is investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRS who underwent endoscopic sinus surgery were investigated. Preoperative computed tomography scans were evaluated. Structured histopathology reporting was performed. The study group was patients with high tissue eosinophil &gt;10\/high power fields (HPF), and the control group was patients with low tissue eosinophil \u226410\/HPF. The radiological relationship of OMC occlusion to the draining sinuses was analyzed in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients with a mean age of 49.7 \u00b1 14.1 years were analyzed. Forty\u2010one (58.6%) patients had high tissue eosinophil &gt;10\/HPF. All patients with ECRS had maxillary disease, and there were 36.2% without OMC occlusion. There was no association of OMC occlusion to either the anterior ethmoid (ECRS: odds ratio [OR], 1.84; 95% confidence interval [CI], 0.24\u201014.14; <jats:italic>P<\/jats:italic> = .55; non\u2010ECRS: OR, 1.57; 95% CI, 0.34\u20107.33; <jats:italic>P<\/jats:italic> = .56) or frontal sinuses (ECRS: OR, 0.67; 95% CI, 0.12\u20103.82; <jats:italic>P<\/jats:italic> = .65; non\u2010ECRS: OR, 1.58; 95% CI, 0.45\u20105.54; <jats:italic>P<\/jats:italic> = .47). For patients with non\u2010ECRS, maxillary sinus diseases was present in 96.2% of those with OMC occlusion and 50% of those without (OR, 25.0; 95% CI, 2.77\u2010226.08; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OMC occlusion is not associated with draining sinuses for patients with ECRS. Simple surgical interventions directed at the OMC are unlikely to be of benefit to this CRS subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23721","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T15:16:55Z","timestamp":1364915815000},"page":"1070-1074","source":"Crossref","is-referenced-by-count":64,"title":["Eosinophilic rhinosinusitis is not a disease of ostiomeatal occlusion"],"prefix":"10.1002","volume":"123","author":[{"given":"Kornkiat","family":"Snidvongs","sequence":"first","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney Australia"},{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck, Skull Base Surgery St. Vincent's Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Sacks","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney Australia"},{"name":"University of Sydney Sydney Australia"},{"name":"Department of Otolaryngology Concord General Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Earls","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology St. Vincent's Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney Australia"},{"name":"Department of Otolaryngology Concord General Hospital Sydney Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00183169"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486709128748"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000124938.46948.c7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900705"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.005"},{"key":"e_1_2_6_7_1","first-page":"45","article-title":"Local IgE production in nonatopic nasal polyposis","volume":"39","author":"Sheahan P","year":"2010","journal-title":"J Otolaryngol Head Neck 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