{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T10:29:27Z","timestamp":1724840967080},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T00:00:00Z","timestamp":1360368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:bold>Objectives\/Hypothesis:<\/jats:bold><\/jats:title><jats:p>Topical Sesame\/Rose geranium oil compound is an effective therapy for hereditary hemorrhagic telangiectasia (HHT) associated epistaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Study Design<\/jats:bold>:<\/jats:title><jats:p>Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Methods<\/jats:bold>:<\/jats:title><jats:p>Twenty patients with HHT confirmed by the Cura\u00e7ao criteria were treated with a sesame\/rose geranium oil topical compound between January 2010 and June 2011. A treatment evaluation survey was conducted at least 3 months after treatment initiation. Changes in epistaxis severity scores (ESS), patient satisfaction, and any adverse effects were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Results<\/jats:bold>:<\/jats:title><jats:p>A total of 20 patients completed the study. The average (SD) age was 54.4 (14.6), and 14 (70%) were female. The median time on rose geranium oil was 183 days (IQR: 114\u2013311). At the conclusion of the study, 18 (90%) were still using rose geranium oil. The majority (75%) of patients subjectively felt improvement with the treatment. The improvement was felt to be gradual in 25% and immediate in 50% of patients. Mean (SD) overall satisfaction using a 10\u2010point Likert scale was 7.8 (3.1), with 50% of the patients reporting a satisfaction rating of 10. Mean (SD) epistaxis severity score (ESS) prior to treatment was 5.3 (1.7). After treatment with sesame\/rose geranium oil, mean (SD) ESS was found to be 3.5 (1.8). Treatment with sesame\/rose geranium oil was associated with a statistically significant improvement in ESS by 1.81 (<jats:italic>P<\/jats:italic> &lt;0.0001). There were no adverse side\u2010effects from the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Conclusion<\/jats:bold>:<\/jats:title><jats:p>A sesame\/rose geranium oil compound can significantly reduce the epistaxis severity scores of patients with hereditary hemorrhagic telangiectasia\u2010related epistaxis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23736","type":"journal-article","created":{"date-parts":[[2013,2,10]],"date-time":"2013-02-10T00:26:51Z","timestamp":1360456011000},"page":"820-822","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of a topical sesame\/rose geranium oil compound in patients with hereditary hemorrhagic telangiectasia associated epistaxis"],"prefix":"10.1002","volume":"123","author":[{"given":"Douglas D.","family":"Reh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.35"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3145"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100136369"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22501"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20065"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302504"},{"key":"e_1_2_6_10_2","first-page":"227","article-title":"Local oestrogen for recurrent epistaxis caused by familial telangiectasia","volume":"38","author":"Tombleson PM","year":"1988","journal-title":"J R Coll Gen Pract"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198203000-00017"},{"key":"e_1_2_6_12_2","first-page":"226","article-title":"Delivery of nasal drops to the middle meatus: which is the best head position?","volume":"39","author":"Karagama YG","year":"2001","journal-title":"Rhinology"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20818"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100110"},{"key":"e_1_2_6_15_2","first-page":"120","article-title":"The role of arterial ligation in intractable epistaxis","volume":"8","author":"Golding\u2010Wood PH","year":"1983","journal-title":"J Laryngol Otol Suppl"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900113"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154749.09303.e0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198412000-00003"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200511"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.5.767"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21415"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:20:25Z","timestamp":1700673625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,9]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/lary.23736"],"URL":"https:\/\/doi.org\/10.1002\/lary.23736","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,9]]}}}