{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:27Z","timestamp":1786978287255,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Long\u2010term vocal overuse or sudden vocal\u2010fold microvascular disruption may lead to the formation of a hypoxic zone of injury and the subsequent release of a cascade of cytokines in the vocal fold. To test this hypothesis, we investigated the expression and the role of hypoxia inducible factor\u20101\u03b1 (HIF\u20101\u03b1) and vascular endothelia growth factor (VEGF) in the formation of vocal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Expression patterns of HIF\u20101\u03b1 and VEGF in surgical specimens of vocal polyps from 36 patients were analyzed using the immunohistochemistry and Western blot method. Normal vocal\u2010fold mucosa from 26 patients who underwent total laryngectomy were collected and used as the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression of HIF\u20101\u03b1 and VEGF were detected both in the vocal polyps group and the control group, while the expression of HIF\u20101\u03b1 and VEGF levels were significantly higher when compared to normal vocal\u2010fold mucosa (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The increased expression of HIF\u20101\u03b1 in vocal polyps indicates that vocal fold overvibration induced hypoxia may play an important role in the pathogenetic mechanism of vocal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      N\/A.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 123:2184\u20132188, 2013\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.23743","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T14:53:56Z","timestamp":1372776836000},"page":"2184-2188","source":"Crossref","is-referenced-by-count":14,"title":["Expression of hypoxia inducible factor\u20101\u03b1 and vascular endothelia growth factor in vocal polyps"],"prefix":"10.1002","volume":"123","author":[{"given":"Rui","family":"Fang","sequence":"first","affiliation":[{"name":"EENT Hospital of Fudan University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J.","family":"Jiang","sequence":"additional","affiliation":[{"name":"EENT Hospital of Fudan University Shanghai People's Republic of China"},{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daquan","family":"Wu","sequence":"additional","affiliation":[{"name":"EENT Hospital of Fudan University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.05.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b24.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20085"},{"key":"e_1_2_7_5_1","first-page":"839","article-title":"Expression of vascular permeability factor in human vocal cord polyps","volume":"20","author":"Wu P","year":"2006","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za 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