{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:58Z","timestamp":1787236558366,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To investigate the association of cleft conditions and the development of secondary cholesteatoma following middle ear ventilation tube insertion (MEVTI) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A retrospective cohort study of all children born after 1980 who underwent at least one MEVTI in a Western Australian hospital from 1980 to 2009 using administrative health data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The timing and number of MEVTIs, adenoidectomy, type of cleft conditions and cholesteatoma were identified along with demographic variables. Flexible parametric proportional hazards models and hazard functions using age as a time scale were used to estimate the relative rate of developing cholesteatoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 56,949 children who underwent at least one MEVTI during the study period. There were 869 (1.5%) children who also had a diagnosis of a cleft condition. Overall, 594 (1.0%) children developed a secondary cholesteatoma. After taking length of follow\u2010up into account, 6.9% (95% confidence interval [CI], 5.0\u20109.6) of children with cleft conditions developed cholesteatoma by 18 years of age compared to 1.5% (95% CI, 1.3\u20101.6) of children without cleft conditions. After adjusting for demographic and clinical variables, children with cleft conditions developed cholesteatoma 7.5 (95% CI, 3.8\u201018.2) times faster after first MEVTI compared to children without cleft conditions, although by the third MEVTI this difference was no longer statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      = .257). The rate of developing cholesteatoma in 2005 to 2009 was 0.5 (95% CI, 0.3\u20100.8) times that of 1980 to 1990.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with cleft conditions are at increased risk of developing cholesteatoma compared to other children who had one or two MEVTIs, although the overall rate of cholesteatoma is declining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2b. Laryngoscope, 123:2024\u20132029, 2013<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.23753","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T18:39:26Z","timestamp":1370371166000},"page":"2024-2029","source":"Crossref","is-referenced-by-count":34,"title":["Cholesteatoma in cleft lip and palate: A population\u2010based follow\u2010up study of children after ventilation tubes"],"prefix":"10.1002","volume":"123","author":[{"given":"Katrina","family":"Spilsbury","sequence":"first","affiliation":[{"name":"Centre for Population Health Research Curtin Health Innovation Research Institute, Curtin University Perth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer F.","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Paediatric Otolaryngology Princess Margaret Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Semmens","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research Curtin Health Innovation Research Institute, Curtin University Perth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Lannigan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Otolaryngology Princess Margaret Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001801.pub3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.113941"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.7.754"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510010711X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199402000-00002"},{"key":"e_1_2_7_7_1","first-page":"S2","article-title":"Guidelines on the management of paediatric middle ear disease","volume":"159","author":"Chant K","year":"1993","journal-title":"Med J Aust"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02928.x"},{"key":"e_1_2_7_9_1","volume-title":"Acute management of infants and children with sore ear\u2014otitis media","author":"NSW Department of Health","year":"2004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.11.1216"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0367-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.03.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20765"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(03)00098-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.020"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00607.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01297.x"},{"key":"e_1_2_7_18_1","volume-title":"Western Australia at a glance","author":"Australian Bureau of Statistics","year":"2012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1998.tb04786.x"},{"key":"e_1_2_7_20_1","volume-title":"International classification of procedures in medicine","author":"World Health Organization","year":"1978"},{"key":"e_1_2_7_21_1","volume-title":"The official NCC Australian version of ICD\u20109\u2010CM index of procedures","author":"Centre NC","year":"1995"},{"key":"e_1_2_7_22_1","volume-title":"Australian Classification of Health Interventions","author":"The National Centre for Classification in Health","year":"2008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2098"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900206"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199204000-00007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132733"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801104"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011907668"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980915)17:17<1973::AID-SIM892>3.0.CO;2-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(03)00074-X"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000172207.59888.a2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.617780"},{"key":"e_1_2_7_33_1","first-page":"A4186","article-title":"Decreasing incidence rate for surgically treated middle ear cholesteatoma in Denmark 1977\u20132007","volume":"57","author":"Djurhuus BD","year":"2010","journal-title":"Dan Med Bull"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23753","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:29:35Z","timestamp":1696361375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,4]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/lary.23753"],"URL":"https:\/\/doi.org\/10.1002\/lary.23753","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,4]]}}}