{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:06:52Z","timestamp":1772161612345,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Several genes have been reported to be upregulated in human nasal polyps in previous genetic analyses. Among these genes, periostin is known to be overexpressed in nasal polyps obtained from aspirin\u2010sensitive patients. Using periostin\u2010null mice, we investigated the role of periostin in a murine model of eosinophilic rhinosinusitis with nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eosinophilic rhinosinusitis was induced in both periostin\u2010null and wild\u2010type mice according to previously established protocols. In brief, ovalbumin (OVA) was used for sensitization and prolonged intranasal stimulation. <jats:italic>Staphylococcus aureus<\/jats:italic> enterotoxin B was applied intranasally to develop polyplike lesions. To examine the inflammation and mucosal lesions, hematoxylin and eosin, Sirius red, and Giemsa staining were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no definite difference in the maximal mucosal thickness between periostin\u2010null and wild\u2010type mice. In contrast, some parameters of inflammation, including the number of polyplike lesions and mast cells, were aggravated in the periostin\u2010null mice compared to wild type. Eosinophilic infiltration was aggravated in the OVA\u2010stimulated periostin\u2010null mice, compared to OVA\u2010stimulated wild\u2010type mice, whereas there was no apparent difference between wild\u2010type and periostin\u2010null mice challenged with additional <jats:italic>S aureus<\/jats:italic> enterotoxin B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The loss of periostin appears to enhance polyplike lesion formation and mast cell infiltration in a mouse model of eosinophilic rhinosinusitis with nasal polyps.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23786","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T20:16:32Z","timestamp":1353442592000},"page":"1075-1081","source":"Crossref","is-referenced-by-count":28,"title":["Periostin may play a protective role in the development of eosinophilic chronic rhinosinusitis with nasal polyps in a mouse model"],"prefix":"10.1002","volume":"123","author":[{"given":"Sang\u2010Wook","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University Hospital Jinju"},{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University Hospital Jinju"},{"name":"Clinical Research Institute Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Gu","family":"Hur","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University Hospital Jinju"},{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Kyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sea\u2010Yuong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University Hospital Jinju"},{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine Boramae Medical Center Seoul 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