{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:08:20Z","timestamp":1762898900477},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Ectopic adrenocorticotropic hormone (ACTH)\u2010secreting tumors account for approximately 10% of Cushing's syndrome (CS). We present an extremely rare case of a patient with CS caused by an ectopic ACTH\u2010secreting pituitary adenoma (EAPA) of the ethmoid sinus. The tumor was identified by positron\u2010emission tomography\u2013computed tomography (PET\/CT) using the somatostatin receptor analogue Ga\u201068\u2010DOTANOC. Transnasal endoscopic resection was performed and the patient showed significant clinical improvement with normalization of the endocrine pituitary axis. Immunostaining showed a somatostatin receptor 2 and 5\u2010positive ACTH\u2010producing adenoma. In patients with ectopic ACTH secretion, Ga\u201068\u2010DOTANOC\u2010PET\/CT may play an important role in the localization of EAPA. Transnasal endoscopic resection is the therapy of choice.<\/jats:p>","DOI":"10.1002\/lary.23867","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T03:32:49Z","timestamp":1357702369000},"page":"1132-1135","source":"Crossref","is-referenced-by-count":20,"title":["Detection of paranasal ectopic adrenocorticotropic hormone\u2010secreting pituitary adenoma by Ga\u201068\u2010DOTANOC positron\u2010emission tomography\u2013computed tomography"],"prefix":"10.1002","volume":"123","author":[{"given":"Johannes A.","family":"Veit","sequence":"first","affiliation":[{"name":"Department of ENT Surgery University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Boehm","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Endocrinology University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Luster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Scheuerle","sequence":"additional","affiliation":[{"name":"Department of Neuropathology University Hospital Ulm\/BKH G\u00fcnzburg G\u00fcnzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Rotter","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Rettinger","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Scheithauer","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20950"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-008-0100-z"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-008-9082-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.97"},{"key":"e_1_2_5_6_1","first-page":"277","article-title":"Clinical applications of 68Ga\u2010DOTANOC in neuroendocrine tumours","volume":"33","author":"Lopci E","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302007000800018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00897.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.23.3.2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32832999c1"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23867","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.23867","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:23:04Z","timestamp":1692534184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/lary.23867"],"URL":"https:\/\/doi.org\/10.1002\/lary.23867","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,8]]}}}