{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:32:48Z","timestamp":1770910368181,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Chronic rhinosinusitis colonized with <jats:italic>Pseudomonas aruginosa<\/jats:italic> is difficult to treat and is related to biofilm formation. Repeated sinus surgery is often required for these patients. Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) is an epithelium\u2010secreted protein that is involved in innate immunity and has anti\u2010<jats:italic>Pseudomonas<\/jats:italic> and antibiofilm functions. This study examined if SPLUNC1 expression was related to sinusitis with bacterial culture positive for <jats:italic>Pseudomonas<\/jats:italic> and the possibility of using SPLUNC1 to predict treatment outcomes for sinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Nonrandomized retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>This was a retrospective study of patients at a tertiary referral center. <jats:italic>Pseudomonas aruginosa<\/jats:italic> infection was compared to clinical variables such as SPLUNC1 mRNA expression levels, immunohistochemical (IHC) stain intensity, Lund\u2010Mackay sinus computed tomography scores, rapid recurrent sinusitis, requirement for repeat sinus surgery, Phadiatop test results, age, gender, nasal polyp(s), and patients' presence\/absence of diabetes mellitus. Comparisons between groups were performed using the \u03c7<jats:sup>2<\/jats:sup> test or Fisher exact test when one confronter was &lt;5. The statistical analyses were carried out with SPSS version 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p><jats:italic>P. aeruginosa<\/jats:italic> sinus infections were associated with lower sinus mucosa SPLUNC1 expression (<jats:italic>P<\/jats:italic> = .0018), weaker SPLUNC1 IHC staining intensity (<jats:italic>P<\/jats:italic> = .011), and poor postoperative outcome (i.e., need repeated sinus surgery) (<jats:italic>P<\/jats:italic> &lt; .001). Other factors were not associated with <jats:italic>Pseudomonas<\/jats:italic> sinus infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Sinusitis with positive <jats:italic>P. aeruginosa<\/jats:italic> bacterial culture is associated with decreased SPLUNC1 sinus mucosa expression. Repeated sinus surgeries are more frequently needed for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23871","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T19:08:18Z","timestamp":1359659298000},"page":"845-851","source":"Crossref","is-referenced-by-count":18,"title":["Decreased SPLUNC1 expression is associated with <i>pseudomonas<\/i> infection in surgically treated chronic rhinosinusitis patients who may require repeated sinus 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