{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:14:29Z","timestamp":1784855669447,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To assess the results of treating idiopathic subglottic stenosis (ISS), determine predictors of treatment success and outcome, and better define roles and limitations of endoscopic and open surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four consecutive patients were treated between 2004 and 2012. Patient, stenosis and treatment details, complications, open surgery rates, and outcomes were recorded. Regression analyses were used to identify predictors of endoscopic treatment success; treatment frequency; and functional outcomes in airway, dyspnea, voice, and swallowing domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were female and mean age at diagnosis was 48 \u00b1 12 years. Symptoms\u2010to\u2010diagnosis latency was 21\u2009\u00b1\u200920 months. There were 10 concomitant glottic and subglottic stenoses. Most lesions were Myer\u2010Cotton grade 3 (48%). Overall, 78% of patients were managed endoscopically. Treatment included intralesional corticosteroids, laser surgery, balloon dilation, and temporary silastic stenting in selected cases. Annual intervention rate was 1.07 \u00b1 0.79. Mean follow\u2010up was 45 months. Factors associated with intervention frequency were stenosis location and severity. Twelve patients underwent anteroposterior laryngotracheal reconstruction with biological inhibition. This resulted in disease remission in all patients with subglottic stenosis, and in most patients with concomitant glottic and subglottic stenosis. Patients with total laryngotracheal stenosis required ongoing treatment for glottic disease. All patients maintained prosthesis\u2010free airways, but in one patient this required a laryngectomy. Most patients achieved good functional outcomes. Stenosis location was the only independent predictor of dyspnea and voice outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ISS can be effectively treated with endoscopic surgery or a bespoke open reconstructive procedure that does not compromise on female voice quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 123:2474\u20132484, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.23949","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T17:58:40Z","timestamp":1375984720000},"page":"2474-2484","source":"Crossref","is-referenced-by-count":88,"title":["Outcome of a multimodality approach to the management of idiopathic subglottic stenosis"],"prefix":"10.1002","volume":"123","author":[{"given":"S. A. R.","family":"Nouraei","sequence":"first","affiliation":[{"name":"National Centre for Airway Reconstruction, Department of Otolaryngology Charing Cross Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Sandhu","sequence":"additional","affiliation":[{"name":"National Centre for Airway Reconstruction, Department of Otolaryngology Charing Cross Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200312000-00011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181648d4a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2002.11.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2007.01474.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen171"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225377.33945.14"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.12.017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-198036"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0355"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100806"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(06)73528-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1742-1241.1995.tb09878.x","article-title":"All that wheezes is not asthma","volume":"49","author":"Scott PM","year":"1995","journal-title":"Br J Clin Pract"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000403"},{"key":"e_1_2_6_15_1","first-page":"719","volume-title":"Surgery of the Trachea and Bronchi","author":"Shapshay SM","year":"2003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20056"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700202"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.10.62"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900771"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-7861.2009.00028.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(97)80061-7"},{"key":"e_1_2_6_22_1","first-page":"379","article-title":"[Use of free skin grafts in surgery of irreducible laryngo\u2010tracheal cicatricial stenosis]","volume":"138","author":"Giraud JC","year":"1954","journal-title":"Bull Acad Natl Med"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800350027008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300410"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215053561549"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.23949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.23949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.23949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:06:11Z","timestamp":1692471971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.23949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/lary.23949"],"URL":"https:\/\/doi.org\/10.1002\/lary.23949","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}