{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:36:58Z","timestamp":1784194618305,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the predictive diagnostic accuracy of the lymphocyte count in Epstein\u2013Barr virus\u2013related infectious mononucleosis (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case note and blood results review within a university\u2010affiliated teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 726 patients undergoing full blood count and Monospot testing was undertaken. Monospot testing outcomes were compared with the lymphocyte count, examining for significant statistical correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a lymphocyte count of \u22644 \u00d7 10<jats:sup>9<\/jats:sup>\/L, 99% of patients had an associated negative Monospot result (sensitivity of 84% and specificity of 94%). A group subanalysis of the population older than 18 years with a lymphocyte count \u22644 \u00d7 10<jats:sup>9<\/jats:sup>\/L revealed that 100% were Monospot negative (sensitivity of 100% and specificity of 97%). A lymphocyte count of \u22644 \u00d7 10<jats:sup>9<\/jats:sup>\/L correlated significantly with a negative Monospot result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A lymphocyte count of \u22644 \u00d7 10<jats:sup>9<\/jats:sup>\/L appears to be a highly reliable predictor of a negative Monospot result, particularly in the population aged &gt;18 years. Pediatric patients, and adults with strongly suggestive symptoms and signs of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>, should still undergo Monospot testing. However, in adults with more subtle symptoms and signs, representing the vast majority, Monospot testing should be restricted to those with a lymphocyte count &gt;4 \u00d7 10<jats:sup>9<\/jats:sup>\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 123:2401\u20132404, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24030","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T20:18:10Z","timestamp":1375733890000},"page":"2401-2404","source":"Crossref","is-referenced-by-count":7,"title":["Use of the lymphocyte count as a diagnostic screen in adults with suspected epstein\u2013barr virus infectious mononucleosis"],"prefix":"10.1002","volume":"123","author":[{"given":"Timothy C.","family":"Biggs","sequence":"first","affiliation":[{"name":"University Hospital Southampton National Health Service Foundation Trust Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"University Hospital Southampton National Health Service Foundation Trust Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Bird","sequence":"additional","affiliation":[{"name":"Portsmouth Hospital National Health Service Trust Portsmouth United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Harries","sequence":"additional","affiliation":[{"name":"University Hospital Southampton National Health Service Foundation Trust Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami J.","family":"Salib","sequence":"additional","affiliation":[{"name":"University Hospital Southampton National Health Service Foundation Trust Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1025428"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00431.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(21)00177-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0197(96)00245-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02187.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.1.61"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmi004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00543-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109000819"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05122.x"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.24030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.24030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:05:55Z","timestamp":1692471955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.24030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/lary.24030"],"URL":"https:\/\/doi.org\/10.1002\/lary.24030","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}