{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:23:39Z","timestamp":1779200619050,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate sleep quality in patients with chronic rhinosinusitis (CRS) using a validated outcome measure and to compare measures of CRS disease severity with sleep dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional evaluation of a multi\u2010center cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>According to the 2007 Adult Sinusitis Guidelines, patients with CRS were prospectively enrolled from four academic, tertiary care centers across North America. Each subject completed the Pittsburgh Sleep Quality Index (PSQI) instrument, in addition to CRS\u2010specific measures of quality\u2010of\u2010life (QOL), endoscopy, computed tomography (CT), and olfaction. Patient demographics, comorbid conditions, and clinical measures of disease severity were compared between patients with \u201cgood\u201d (PSQI; \u22645) and \u201cpoor\u201d (PSQI;\u2009&gt;\u20095) sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (n\u2009=\u2009268) reported a mean PSQI score of 9.4 (range: 0\u201321). Seventy\u2010five percent of patients reported PSQI scores above the traditional cutoff, indicating poor sleep quality. Patients with poor sleep quality were found to have significantly worse QOL scores on both the Rhinosinusitis Disability Index (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 22\u2010item Sinonasal Outcome Test (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). No significant differences in average endoscopy, CT, or olfactory function scores were found between patients with good or poor sleep quality. Tobacco smokers reported worse average PSQI total scores compared to nonsmokers (<jats:italic>P<\/jats:italic>\u2009=\u20090.030). Patients reporting poor sleep were more likely to have a history of depression, even after controlling for gender (<jats:italic>P<\/jats:italic>\u2009=\u20090.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS\u2010specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 123:2364\u20132370, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24040","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T17:39:02Z","timestamp":1375983542000},"page":"2364-2370","source":"Crossref","is-referenced-by-count":124,"title":["Sleep quality and disease severity in patients with chronic rhinosinusitis"],"prefix":"10.1002","volume":"123","author":[{"given":"Jeremiah A.","family":"Alt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Rhinology and Sinus Surgery Oregon Sinus Center, Oregon Health and Science University Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Rhinology and Sinus Surgery Oregon Sinus Center, Oregon Health and Science University Portland Oregon"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Rhinology and Sinus Surgery Medical University of South Carolina Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Rhinology and Sinus Surgery Oregon Sinus Center, Oregon Health and Science University Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck 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