{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:01:43Z","timestamp":1791986503279,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Laryngeal transplantation offers the potential for patients without a larynx to recover their voice, which is critical in our communication age. We report clinical and functional outcomes from a laryngotracheal transplant. Widespread adoption of this technique has been slowed due to the ethical concerns of life\u2010long immunosuppression after a nonvital organ transplant. Our patient was already on immunosuppressive medication from prior kidney\u2013pancreas transplantation, and therefore was not exposed to added long\u2010term risk. We describe the unique technical advances, clinical course, and rehabilitation of this patient and the implications for future laryngeal transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A laryngotracheal transplantation was performed in a 51\u2010year\u2010old prior kidney\u2013pancreas transplant recipient presenting with complete laryngotracheal stenosis. Surgical modifications were made in the previously described technique related to retrieval, vascular supply, and reinnervation. This resulted in a robustly vascularized organ with well\u2010perfused long\u2010segment tracheal transplant and early return of motor reinnervation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A multidisciplinary approach resulted in a successful transplant without evidence of rejection to date. Postoperatively, the patient continues to rely on a tracheotomy but has had the return of an oral and nasal airway, vocalization, smell, and taste, all experienced for the first time in 11 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated that our methods may result in a successful laryngotracheal transplant. We describe the preparation, surgical technique, rehabilitation, and interventions employed in achieving optimal outcomes. This report contributes valuable information on this rarely performed composite transplant. <jats:italic>Laryngoscope<\/jats:italic>, 123:2502\u20132508, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24053","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T09:02:37Z","timestamp":1363165357000},"page":"2502-2508","source":"Crossref","is-referenced-by-count":54,"title":["Laryngotracheal transplantation"],"prefix":"10.1002","volume":"123","author":[{"given":"D. Gregory","family":"Farwell","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Davis, Sacramento California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Birchall","sequence":"additional","affiliation":[{"name":"Ear Institute, Royal National Throat Nose and Ear Hospital, University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Macchiarini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention, and Technology Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang C.","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Davis, Sacramento California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo M.","family":"de Mattos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Transplant Nephrology University of California Davis, Sacramento California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Gallay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Transplant Nephrology University of California Davis, Sacramento California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard V.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of California Davis, Sacramento California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Grow","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of California Davis, Sacramento California 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