{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:28:40Z","timestamp":1782980920538,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To carry out a pharmacoeconomic analysis of <jats:italic>Cyclamen europaeum<\/jats:italic> (<jats:italic>CE<\/jats:italic>) in the management of acute rhinosinusitis (ARS) in Spain using data from the PROSINUS (PROspective epidemiological study of the diagnosis and treatment of acute rhinoSINUSitis) study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This was a prospective observational study to compare the effectiveness and cost\u2010effectiveness between therapies including <jats:italic>CE<\/jats:italic> versus other therapies in the management of ARS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out as a secondary analysis of the PROSINUS study, combining healthcare resource use, productivity loses, and health outcomes from the observational study, with costs representative of the Spanish Health System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>CE<\/jats:italic> given as monotherapy appears to be more effective (cure rate) than other monotherapies (15.3% higher, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and combination (10.3% higher, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) therapies. The addition of <jats:italic>CE<\/jats:italic> to other single\u2010drug or combination therapies showed a statistically significant improvement in terms of cure rates when adding <jats:italic>CE<\/jats:italic> to two\u2010drug combinations (93.9% vs. 76.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and no significant effect when added to combinations of three or more drugs (81.1% vs. 79.8; nonsignificant). <jats:italic>CE<\/jats:italic>\u2010based therapies generally showed lower indirect costs, although only the comparison of <jats:italic>CE<\/jats:italic> alone versus other monotherapies, with a net cost savings of \u20ac101 per patient, reached statistical significance (\u20ac331 vs. \u20ac432, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). In addition, <jats:italic>CE<\/jats:italic>\u2010based therapies show lower cost per cured patient in all comparisons, except when <jats:italic>CE<\/jats:italic> was used in combination with three or more other drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of CE (Nasodren<jats:sup>\u00ae<\/jats:sup>) may be associated to better clinical outcomes at no additional cost for the healthcare system with respect to treatments commonly used for ARS in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2c. <jats:italic>Laryngoscope<\/jats:italic>, 123:2620\u20132625, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24167","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T16:16:32Z","timestamp":1368461792000},"page":"2620-2625","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacoeconomics of Cyclamen europaeum in the management of acute rhinosinusitis"],"prefix":"10.1002","volume":"123","author":[{"given":"Joaquim","family":"Mullol","sequence":"first","affiliation":[{"name":"Rhinology Unit and Smell Clinic, ENT Department Hospital Cl\u00ednic, IDIBAPS, CIBERES Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Crespo","sequence":"additional","affiliation":[{"name":"Rhinology Unit and Smell Clinic, ENT Department Hospital Cl\u00ednic, IDIBAPS, CIBERES Barcelona Spain"},{"name":"Department of Statistics University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Hartington Pharmaceuticals Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Brosa","sequence":"additional","affiliation":[{"name":"Oblikue Consulting Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"129","article-title":"Symptoms of rhinosinusitis","volume":"49","author":"Fokkens WJ","year":"2011","journal-title":"Rhinology"},{"key":"e_1_2_6_3_1","first-page":"45","article-title":"Diagnosis and treatment of acute rhinosinusitis: second consensus [in Spanish]","volume":"21","author":"Barberan MT","year":"2008","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998901030S502"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.169"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.027"},{"key":"e_1_2_6_7_1","first-page":"2869","article-title":"Nasal steroids for acute sinusitis. A survey of a Cochrane review [in Danish]","volume":"170","author":"Lous J","year":"2008","journal-title":"Ugeskr Laeger"},{"issue":"20","key":"e_1_2_6_8_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps Group. European Position Paper on Rhinosinusitis and Nasal Polyps 2007","volume":"45","author":"Fokkens WJ","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.044"},{"key":"e_1_2_6_10_1","unstructured":"Montserrat\u2010GiliJR MullolJ.Prospective epidemiological study of the diagnosis and therapeutic management of acute rhinosinusitis in Spain. In: 22nd Congress of European Rhinologic Society (ERS) and & 27th International Symposium of Infection and Allergy of the Nose (ISIAN). Crete (Greece) June 15th\u201319th 2008. 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Accessed December 21 2010."},{"key":"e_1_2_6_16_1","unstructured":"PonikauJU HamilosDJ BarretoA CecilJ JonesSW MantheiSE.Efficacy and safety of a Cyclamen europaeum extract nasal spray in acute sinusitis: a randomized clinical trial. In: 1st Congress of the Confederation of the European ORL\u2010HNS; July 2nd\u20136th 2011. Barcelona Spain. 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