{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:10:20Z","timestamp":1769166620106,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The aims of this study were to evaluate the efficacy of functional endoscopic sinus surgery (FESS)\u2013oriented multimodality treatment in chronic rhinosinusitis (CRS) patients with asthma and its impact on asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, nonrandomized cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven CRS patients with asthma who underwent FESS with postoperative topical corticosteroid spray were evaluated preoperatively; 25 of them were evaluated 1 year and 3 years postoperatively. CRS was evaluated by visual analogue scale, clinical control of CRS, and objective measurement endoscopy Lund\u2010Kennedy scores. Asthma was assessed by subjective asthma control test and asthma control level, also by objective antiasthma medication use and pulmonary function tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VAS scores of general symptoms (8.09\u2009\u00b1\u20090.87 preoperatively) were significantly improved at 1 year (2.94\u2009\u00b1\u20092.21) and 3 years (3.77\u2009\u00b1\u20092.16) postoperation (<jats:italic>P<\/jats:italic>\u2009=\u2009.000). No difference in these items was found between 1 year and 3 years (<jats:italic>P<\/jats:italic>\u2009=\u2009.463). Endoscopy Lund\u2010Kennedy scores at 1 year (4.34\u2009\u00b1\u20093.09) and 3 years (5.80\u2009\u00b1\u20093.38) postoperatively were significantly better (9.33\u2009\u00b1\u20092.03 preoperatively, <jats:italic>P<\/jats:italic>\u2009=\u2009.000), and there was no difference between 1 year and 3 years of follow\u2010up (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Significantly, asthma control level improved postoperatively (<jats:italic>P<\/jats:italic>\u2009=\u2009.025). However, antiasthma drug and pulmonary function showed no significant change postoperatively (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FESS\u2010oriented multimodality treatment improves CRS with asthma significantly and persistently. Asthma control level improved. Antiasthma medication use and pulmonary function remained stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 124:24\u201328, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24196","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T08:24:55Z","timestamp":1369038295000},"page":"24-28","source":"Crossref","is-referenced-by-count":44,"title":["Long\u2010term results of endoscopic sinus surgery\u2013oriented treatment for chronic rhinosinusitis with asthma"],"prefix":"10.1002","volume":"124","author":[{"given":"Feng\u2010Hong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Hospital and Otolaryngology Institute Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke\u2010Jun","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital and Otolaryngology Institute Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Biao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Respiratory , First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory , First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital and Otolaryngology Institute Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital and Otolaryngology Institute Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Bo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital and Otolaryngology Institute Sun Yat\u2010Sen University Guangzhou Guangdong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_3_1","first-page":"110","article-title":"Prevalence of lower airway diseases in patients with chronic 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