{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:36:11Z","timestamp":1761975371776},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To demonstrate that quality\u2010of\u2010life outcomes after endoscopic sinus surgery are not compromised in patients with Samter's triad (asthma, nasal polyps, aspirin sensitivity) when compared to patients with eosinophilic chronic rhinosinusitis with nasal polyposis (eCRSwP) who are not aspirin sensitive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review of prospectively collected data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients with Samter's triad were identified from a prospectively collected patient database from 2003 to 2012. Preoperative and postoperative symptom and endoscopy scores were compared to those of 37 consecutive patients with eCRSwP who were not aspirin sensitive (control). Student <jats:italic>t<\/jats:italic> test and Fisher exact test were used to examine for differences between the two groups. Symptom scores were assessed using the 20\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201020). Endoscopy findings were scored according to the Lund\u2010Kennedy methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Samter's triad patients had significantly worse disease preoperatively when compared to the control group: SNOT\u201020 (31.1 vs. 22.1, <jats:italic>P<\/jats:italic>\u2009=\u2009.004), endoscopy score (10.9 vs. 7.6, <jats:italic>P<\/jats:italic>\u2009=\u2009.0005), and Lund\u2010Mackay computed tomography score (18.9 vs. 13.9, <jats:italic>P<\/jats:italic>\u2009=\u2009.0001). Although postoperative endoscopy scores remained worse in the Samter's triad group, postoperative SNOT\u201020 scores were comparable to those of the control group at \u22653 years follow\u2010up (22.8 vs. 17.3, <jats:italic>P<\/jats:italic>\u2009=\u2009.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality\u2010of\u2010life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease\u2010specific, validated outcomes instrument in comparing Samter's triad patients with aspirin\u2010tolerant patients who have nasal polyposis and tissue eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 124:34\u201337, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24220","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T14:24:43Z","timestamp":1369664683000},"page":"34-37","source":"Crossref","is-referenced-by-count":23,"title":["Aspirin sensitivity does not compromise quality\u2010of\u2010life outcomes in patients with samter's triad"],"prefix":"10.1002","volume":"124","author":[{"given":"David W.","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University Augusta Georgia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett T.","family":"Comer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University Augusta Georgia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios A.","family":"Lachanas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University Augusta Georgia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stilianos E.","family":"Kountakis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University Augusta Georgia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_6_3_1","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"107","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.06030391"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI620"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013508"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446702"},{"key":"e_1_2_6_10_1","first-page":"7","article-title":"Outcome analysis of endoscopic sinus surgery for chronic sinusitis in patients having Samter's triad","volume":"29","author":"Amar YG","year":"2000","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_11_1","first-page":"91","article-title":"Endoscopic surgical treatment of sinonasal polyposis\u2010medium term outcomes (mean follow\u2010up of 5 years)","volume":"41","author":"Garrel R","year":"2003","journal-title":"Rhinology"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318170af1e"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180333121"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147917.43615.c0"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.24220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.24220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:20:42Z","timestamp":1692559242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.24220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/lary.24220"],"URL":"https:\/\/doi.org\/10.1002\/lary.24220","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}