{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:32:53Z","timestamp":1773480773920,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Hypothesis<\/jats:title>\n                    <jats:p>Acinic cell carcinoma (AciCC) is a rare salivary gland malignancy that most commonly arises in the parotid gland. Characteristics of AciCC are slow growth and a long clinical course. As a rare tumor, population\u2010based studies are limited. We analyzed the incidence and survival for AciCC using a national population\u2010based database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and disease\u2010specific survival trends for AciCC between 1973 and 2009. Patient data were stratified according to age, gender, race, grade, and extent of disease. Incidence trends were studied across the last 30 years and long\u2010term disease\u2010specific survival outcomes were compared across the different demographic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,129 cases of AciCC were identified, comprising of 672 (59.52%) females. Incidence trend analysis revealed significant changes in yearly incidence rates from 1973 to 2009 for male gender and white and \u201cothers\u201d races. Overall 5\u2010year survival was 97.15%, 10\u2010year survival was 93.81%, and 20\u2010year survival was 89.74%. Significant differences in survival outcomes were noted for extent of disease. Patients exhibiting distant metastasis displayed the worse long\u2010term prognosis at 21.99% 20\u2010year disease\u2010specific survival. Hazard ratios demonstrated a significant increase in mortality in patients with poorly differentiated, undifferentiated, and metastatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Trends in incidence of AciCC are influenced by gender, race and age. Long\u2010term survival of this rare malignant tumor is influenced by gender, grade, race, and extent of disease. Future studies need to be conducted to investigate these dynamic trends related to AciCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2b.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 124:172\u2013178, 2014\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.24231","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T05:49:11Z","timestamp":1370929751000},"page":"172-178","source":"Crossref","is-referenced-by-count":86,"title":["Demographic trends and disease\u2010specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases"],"prefix":"10.1002","volume":"124","author":[{"given":"Neal R.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Neurological Institute of New Jersey Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurin","family":"Sanghvi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Neurological Institute of New Jersey Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohemmed N.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Neurological Institute of New Jersey Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qasim","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Neurological Institute of New Jersey Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of 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