{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:36:51Z","timestamp":1775176611142,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine clinical and pathological correlates of outcome among patients treated by surgery and postoperative radiation therapy for mucoepidermoid carcinoma of the parotid gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 61 patients treated by surgery and postoperative radiation therapy for localized mucoepidermoid carcinoma of the parotid gland were retrospectively reviewed in an attempt to identify clinicopathologic correlates of overall survival. Secondary endpoints included local\u2010regional control, distant metastasis\u2010free survival, and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010 and 5\u2010year estimates of overall survival were 85% and 79%, respectively. Multivariate analysis identified high tumor grade (hazard ratio [HR]\u2009=\u20097.92) and T4 disease (HR\u2009=\u20093.35) as independent predictors of decreased survival, with the former also predicting for distant metastasis and the latter predicting for local\u2010regional recurrence. The 5\u2010year estimate of overall survival was 83% for patients with non\u2010high\u2010grade tumors, compared to 52% for those with high\u2010grade histology (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Late complications included trismus (2 patients), osteoradionecrosis (1 patient), and hearing loss (1 patient).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with high\u2010grade tumors and T4 disease are at increased risk for treatment failure after surgery and postoperative radiation therapy for mucoepidermoid carcinoma of the parotid gland. Investigative strategies to improve outcome should be considered for these particular patients in the future.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 123:3049\u20133055, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24238","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T09:28:48Z","timestamp":1370942928000},"page":"3049-3055","source":"Crossref","is-referenced-by-count":52,"title":["Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome"],"prefix":"10.1002","volume":"123","author":[{"given":"Allen M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California, Davis School of Medicine Sacramento California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie H.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California, Davis School of Medicine Sacramento California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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