{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:29:24Z","timestamp":1760549364059},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the effectiveness of gelatin\u2010thrombin matrix for first line treatment of posterior epistaxis. Secondarily, we evaluated discomfort during treatment and the cost savings of treatment with gelatin\u2010thrombin matrix compared to posterior packing, endoscopic, or endovascular treatment at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective pilot, nonblinded, noncontrolled registered clinical trial (NCT01098578).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with posterior epistaxis were enrolled into this study. Gelatin\u2010thrombin matrix was used for posterior epistaxis treatment with simultaneous ipsilateral choanal occlusion. Patients were discharged within 2 hours of being successfully treated. A visual analog scale (range 0\u201310) was used to assess treatment discomfort. Patients were evaluated in clinic 5 and 30 days after treatment to assess for intranasal complications and recurrent epistaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gelatin\u2010thrombin matrix successfully treated epistaxis in 80% of the patients. The procedure was associated with a mean discomfort of 3.6 (range 0\u20139.7). The institutional per case cost of treatment of patients with posterior epistaxis with gelatin\u2010thrombin matrix is 80.3%, 87.4%, and 89.4% less than with endoscopic surgery, posterior packing, or embolization, respectively. There were no complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study demonstrated that gelatin\u2010thrombin matrix is a safe and both a clinically effective and cost\u2010saving means of treating posterior epistaxis. In this study, its use is associated with a low level of discomfort. This treatment method may improve the quality of care for patients with posterior epistaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 124:38\u201342, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24240","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T09:42:47Z","timestamp":1370943767000},"page":"38-42","source":"Crossref","is-referenced-by-count":27,"title":["Prospective clinical trial of gelatin\u2010thrombin matrix as first line treatment of posterior epistaxis"],"prefix":"10.1002","volume":"124","author":[{"given":"Shaun J.","family":"Kilty","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Ottawa Ottawa Canada"},{"name":"The Ottawa Hospital Ottawa Canada"},{"name":"The Ottawa Hospital Research Institute (OHRI) Ottawa 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