{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:33:46Z","timestamp":1779294826726,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The KiSS\u20101 gene has been reported to serve as a metastasis suppressor gene in various human malignancies. However, no information is available regarding the role of the KiSS\u20101 gene or its gene product kisspeptin in nasopharyngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Kisspeptin and its receptor AXOR12 expression were assessed using immunohistochemistry in paraffin\u2010embedded tumor tissues from 140 patients diagnosed with nasopharyngeal carcinoma. Immunoreactivity was quantified, and its relationships with patients' clinical parameters and survival were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using a 50% cutoff level, the immunoreactivities of kisspeptin and AXOR12 were divided into low and high expression. The expression levels of kisspeptin and AXOR12 in nasopharyngeal carcinoma were well correlated with each other (r<jats:sub>s<\/jats:sub>\u2009=\u200919.31<jats:italic>, P<\/jats:italic>\u2009&lt;\u20090.01). Low expression of kisspeptin in nasopharyngeal carcinoma was correlated with clinical stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), N stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), and metastasis (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Patients with low kisspeptin expression had poorer distant metastasis\u2010free survival than those with high kisspeptin expression (75.32% vs. 83.79%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Although neither kisspeptin nor AXOR12 were found to be prognostic factors for overall survival, kisspeptin was determined to be an independent prognostic factor for distant metastasis\u2010free survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) using multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we report for the first time that low kisspeptin expression in nasopharyngeal carcinoma is correlated with poor clinical outcome; kisspeptin could serve as an independent prognostic marker for metastasis in nasopharyngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A. <jats:italic>Laryngoscope<\/jats:italic>, 124:E167\u2013E174, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24467","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T20:46:48Z","timestamp":1384894008000},"source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of kisspeptin expression in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"124","author":[{"given":"Tai\u2010Ze","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong\u2010Fen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Outpatient Cancer Center of Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai\u2010Ji","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Tumor Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Globocan2008:Estimated cancer incidence mortality prevalence and disability\u2010adjusted life years (DALYs) worldwide in 2008. Available at:http:\/\/globocan.iarc.fr."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25754"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.23.1731"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<1035::AID-IJC20>3.0.CO;2-B"},{"key":"e_1_2_6_7_1","first-page":"2384","article-title":"Suppression of metastasis in human breast carcinoma MDA\u2010MB\u2010435 cells after transfection with the metastasis suppressor gene, KiSS\u20101","volume":"57","author":"Lee JH","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104847200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102743200"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35079135"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1519-02"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20357"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.39"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0521"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1636-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.02.048"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20950"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1519-02"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.024"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e3283559cbe"},{"key":"e_1_2_6_22_1","first-page":"7422","article-title":"Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3\u2010q23","volume":"61","author":"Shirasaki F","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_23_1","first-page":"348","article-title":"Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss\u20101, and prognosis in patients with non\u2010small cell lung cancer","volume":"15","author":"Wang G","year":"2012","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.03.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0352-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63854-0"},{"key":"e_1_2_6_27_1","first-page":"263","article-title":"Effect of KISS\u20101 on invasive potential and proliferation of esophageal squamous carcinoma cell line EC\u20101","volume":"38","author":"Li N","year":"2009","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-005-4180-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-003-0469-z"},{"key":"e_1_2_6_30_1","first-page":"5399","article-title":"Identification and characterization of mouse metastasis\u2010suppressor KiSS1 and its G\u2010protein\u2010coupled receptor","volume":"62","author":"Stafford LJ","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00971"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0763"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.24467","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.24467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:10:43Z","timestamp":1692544243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.24467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,19]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/lary.24467"],"URL":"https:\/\/doi.org\/10.1002\/lary.24467","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,19]]}}}