{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:41:51Z","timestamp":1696570911080},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Paranasal sinus pneumatization in patients with cystic fibrosis (CF) is less extensive compared to the general population and seems to be correlated to CF genotype. Interestingly, in CF patients temporal bone pneumatization (TBP) is more extensive compared to the general population, and middle ear pathology is generally uncommon in CF. It is debated whether TBP is influenced environmentally or genetically. The aim of the present study was to investigate pneumatization of the temporal bone in patients with CF and to correlate this with genotype and paranasal sinus volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective collection of data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 104 adult CF patients, computed tomography of the temporal bone and the paranasal sinuses was performed. TBP was graded using a validated scoring system. Patients were divided into two groups, mild and severe CF, based on their mutations in the CF transmembrane conductance regulator gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 31 patients with mild CF, 71% had extensive TBP, and of the 73 patients with severe CF, 82% had extensive pneumatization of the temporal bone. TBP did not differ significantly for CF genotype, and TBP was not correlated to paranasal sinus volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whereas paranasal sinus pneumatization in CF patients seems to be related to CF genotype among other influencing factors, this study showed no correlation between TBP and CF genotype. TBP was not correlated to paranasal sinus volume. Hypothetically, in CF, pneumatization of the temporal bone is under a different influence than paranasal sinus pneumatization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 124:1682\u20131686, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24575","type":"journal-article","created":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T04:16:38Z","timestamp":1388204198000},"page":"1682-1686","source":"Crossref","is-referenced-by-count":9,"title":["Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?"],"prefix":"10.1002","volume":"124","author":[{"given":"Maaike C.","family":"Berkhout","sequence":"first","affiliation":[{"name":"Departments of Pulmonology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J.","family":"van Rooden","sequence":"additional","affiliation":[{"name":"Radiology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph C.","family":"Aalbers","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lahssan H.","family":"el Bouazzaoui","sequence":"additional","affiliation":[{"name":"Departments of Pulmonology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wytske J.","family":"Fokkens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Academic Medical Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert","family":"Rijntjes","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry G. M.","family":"Heijerman","sequence":"additional","affiliation":[{"name":"Departments of Pulmonology Haga Teaching Hospital the Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200012)30:6<481::AID-PPUL8>3.0.CO;2-N"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446676"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.07.037"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2001.420509.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199309000-00008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23392"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2905"},{"key":"e_1_2_6_9_1","first-page":"233","article-title":"Temporal bone pneumatization and its relationship to paranasal sinus development in cystic fibrosis","volume":"48","author":"Seifert CM","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21404"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.1.75"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198810000-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029497"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.03.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2007.04.019"},{"key":"e_1_2_6_16_1","article-title":"Sinonasal manifestations of cystic fibrosis: a correlation between genotype and phenotype?","author":"Berkhout MC","journal-title":"J Cyst Fibros"},{"key":"e_1_2_6_17_1","first-page":"S88","article-title":"A comparative study of the pneumatization of the mastoid air cells and the frontal and maxillary sinuses","volume":"10","author":"Thomas A","year":"1989","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-009-0618-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00241.x"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.24575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:39:29Z","timestamp":1696495169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.24575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,6]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/lary.24575"],"URL":"https:\/\/doi.org\/10.1002\/lary.24575","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,6]]}}}