{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:42:32Z","timestamp":1773358952737,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Laryngeal chondrosarcoma (LC) is a rare entity, reportedly comprising less than 1% of all laryngeal tumors. Consequently, the incidence and survival of patients with this slow\u2010growing tumor has been difficult to study. Our objective was to evaluate incidence, organized by patient demographics, as well as long\u2010term survival trends of this malignancy using a population\u2010based database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SEER database was searched for patients diagnosed with LC between 1973 and 2010. Data analyzed included patient demographics, incidence, treatment modality, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and forty\u2010three cases were identified, representing 0.2% of all laryngeal tumors. Median age at diagnosis was 61.7 years. Men and women constituted 76.2% and 23.8% of patients, respectively. Tumors were locally invasive with 37.7% T4 disease and infrequent regional and distant metastases. The 1\u2010year, 5\u2010year, and 10\u2010year disease\u2010specific survival for LC was 96.5%, 88.6%, and 84.8%, respectively, compared to 88.3%, 68.2%, and 59.3%, respectively for patients with all other laryngeal tumors (<jats:italic>P<\/jats:italic> values\u2009&lt;\u20090.01). Relative survival was 94.9% at 1 year, 88.5% at 5 years, and 88.4% at 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis represents the largest LC study sample to date, allowing for evaluation of incidence and long\u2010term survival. LC occurs infrequently, is locally invasive, but only rarely metastasizes. Prognosis for LC is significantly better than for other laryngeal malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 124:1877\u20131881, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24618","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:23:00Z","timestamp":1390990980000},"page":"1877-1881","source":"Crossref","is-referenced-by-count":78,"title":["Laryngeal chondrosarcoma: A population\u2010based analysis"],"prefix":"10.1002","volume":"124","author":[{"given":"Pariket M.","family":"Dubal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Svider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Wayne State University School of Medicine (P.F.S.) Detroit Michigan U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek V.","family":"Kanumuri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey (S.B., J.A.E.) Newark New Jersey"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23957"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/095952871600700109"},{"key":"e_1_2_6_4_1","first-page":"681","article-title":"Chondrosarcoma of the larynx","volume":"14","author":"Buda I","year":"2012","journal-title":"IMAJ"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200207000-00002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<108::AID-CNCR13>3.0.CO;2-6"},{"key":"e_1_2_6_7_1","first-page":"2925","article-title":"Chondrosarcoma of the larynx and review of the literature","volume":"27","author":"Sauter A","year":"2007","journal-title":"Anticancer 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