{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:06:53Z","timestamp":1777000013836,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To look for predictors of respiratory epithelial adenomatoid hamartomas (REAH) development in patients operated for nasal polyposis (NP) by adjusting on confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and six patients with NP, endoscopically operated between September 2009 and March 2012 on the ethmoidal labyrinths and olfactory clefts, were enrolled in this study. Clinical data was collected 1 day prior to surgery by using a standard grid without knowledge of any histological features. Patients were then divided into two groups based on operative and pathological reports: with and without REAH in the olfactory cleft (REAH\u2010OC). The multivariate logistic regression model was used to assess independent factors linked to the presence of REAH\u2010OC in patients with NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean duration of NP disease in patients with REAH\u2010OC was about 13.95\u2009\u00b1\u200910.8 years versus 5.7\u2009\u00b1\u20095.6 years in patients without REAH\u2010OC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Seventy\u2010four percent of patients with REAH\u2010OC had undergone one or more NP\u2010related surgeries in their lifetime, in contrast with 49.21% of patients without REAH\u2010OC (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). According to the multivariate logistic regression analysis, those patients experiencing NP\u2009\u2265\u200910 years (OR 4.0, 95% CI 1.304\u201312.062, <jats:italic>P<\/jats:italic>\u2009=\u20090.015) and those with asthma (OR 2.5, 95% CI 1.004\u20136.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were at an increased risk of developing REAH\u2010OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The development of REAH in patients with NP appears as a specific disease of the mucosa of the OC, induced by a long\u2010lasting and\/or severe inflammation of the olfactory clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 124:2461\u20132465, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24778","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T11:21:22Z","timestamp":1402658482000},"page":"2461-2465","source":"Crossref","is-referenced-by-count":26,"title":["Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis"],"prefix":"10.1002","volume":"124","author":[{"given":"Duc T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of ENT\u2013Head and Neck Surgery University Hospital of Nancy Nancy France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) CIC\u2010EC CIE6 Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phi\u2010Linh","family":"Nguyen\u2010Thi","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Evaluation Department University Hospital of Nancy Nancy France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) CIC\u2010EC CIE6 Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Gauchotte","sequence":"additional","affiliation":[{"name":"Department of Pathology INSERM U954, University of Lorraine Nancy France"},{"name":"Faculty of Medicine University of Lorraine Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Arous","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Lorraine Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean M.","family":"Vignaud","sequence":"additional","affiliation":[{"name":"Department of Pathology INSERM U954, University of Lorraine Nancy France"},{"name":"Faculty of Medicine University of Lorraine Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of ENT\u2013Head and Neck Surgery University Hospital of Nancy Nancy France"},{"name":"Faculty of Medicine University of Lorraine Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3905"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21083"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22399"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1713-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3907"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400809"},{"key":"e_1_2_6_8_1","first-page":"264","article-title":"Respiratory adenomatoid hamartoma must be suspected on CT\u2010scan enlargement of the olfactory clefts","volume":"44","author":"Lima NB","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1755"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.10.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.137.8.820"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2012.04.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3345"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000092"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590103"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10047"},{"key":"e_1_2_6_17_1","first-page":"33","volume-title":"WHO Classification of Tumours Pathology and Genetics of Head and Neck Tumours","author":"Wenig BM","year":"2005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10642"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130708600719"},{"key":"e_1_2_6_20_1","first-page":"40","article-title":"Chronic rhinosinusitis and nasal polyposis; 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